{"id":"W2793588008","doi":"10.1016/j.xphs.2018.03.015","title":"Exploring a Kinetic Model Approach in Biopharmaceutics: Estimating the Fraction Absorbed of Orally Administered Drugs in Humans","year":2018,"lang":"en","type":"article","venue":"Journal of Pharmaceutical Sciences","topic":"Drug Solubulity and Delivery Systems","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":16,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"","keywords":"Pharmacokinetics; Biopharmaceutics; Absorption (acoustics); Chemistry; Fraction (chemistry); Oral administration; Pharmacology; Chromatography; Materials science; Medicine; Biological activity; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.006959368,0.0002360387,0.0005124927,0.000458702,0.0002808725,0.00005998968,0.0008648081,0.0001570153,0.0001609397],"category_scores_gemma":[0.0002507286,0.0001670085,0.000153553,0.001080228,0.001380383,0.0007824673,0.0001301858,0.001263702,0.00001734349],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001440473,"about_ca_system_score_gemma":0.0002728094,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004740536,"about_ca_topic_score_gemma":0.00002036523,"domain_scores_codex":[0.9961604,0.0008669648,0.001390118,0.0003173353,0.0006627092,0.0006024089],"domain_scores_gemma":[0.9979625,0.0007365054,0.0006754767,0.0001470433,0.000233224,0.0002452332],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.005994747,0.006160313,0.148349,0.001234446,0.0004672505,0.0001878977,0.0618539,0.5026011,0.1695389,0.007174626,0.001036296,0.0954016],"study_design_scores_gemma":[0.002501023,0.0004183158,0.003524895,0.000170778,0.0001089816,0.0000613393,0.002835433,0.9741517,0.01289508,0.0009527479,0.002132837,0.0002469117],"study_design_candidate":"simulation_or_modeling","study_design_consensus":"simulation_or_modeling","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9908066,0.0005401791,0.001780243,0.0008993303,0.001491124,0.0003531317,0.000006609872,0.0000159926,0.004106726],"genre_scores_gemma":[0.9946788,0.0002201966,0.003896882,0.0006563145,0.0004860793,0.00001948328,5.814245e-7,0.00001272852,0.00002894618],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4715506,"threshold_uncertainty_score":0.6810411,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.4602309921466093,"score_gpt":0.4932297930682922,"score_spread":0.03299880092168289,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}