{"id":"W2793596916","doi":"10.1016/j.bpj.2017.11.2934","title":"Single Virion Super-Resolution Microscopy Unveils Mechanistic Details of Env Glycoprotein Recognition by the Broadly Neutralizing HIV-1 Antibodies 4E10 and 10E8","year":2018,"lang":"en","type":"article","venue":"Biophysical Journal","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Hospital for Sick Children","funders":"","keywords":"Antibody; Neutralization; Glycoprotein; Viral envelope; Epitope; Lipid bilayer; Biophysics; Viral entry; Neutralizing antibody; Virology; Chemistry; Virus; Viral membrane; Biology; Membrane; Cell biology; Viral replication; Biochemistry; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000343815,0.000223252,0.0002083995,0.0001780798,0.0003433501,0.0005250653,0.0006536638,0.0007736005,0.002159006],"category_scores_gemma":[0.0003305073,0.0002842284,0.0002721889,0.0001016375,0.0004943979,0.001028605,0.0003300001,0.001513631,0.0004813608],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005338686,"about_ca_system_score_gemma":0.0003549329,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009754461,"about_ca_topic_score_gemma":0.001233284,"domain_scores_codex":[0.9998517,0.00001583717,0.0000041259,0.00002349813,0.00005100847,0.00005375708],"domain_scores_gemma":[0.9998156,0.0000831833,0.00002360162,0.0000318332,0.00002081102,0.00002487684],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006363888,0.00003288137,0.0004159698,0.00004201142,0.000007420521,0.0001104948,0.00006180935,0.001032863,0.9914281,0.002975868,0.0003537561,0.003475128],"study_design_scores_gemma":[0.00003892905,0.0001845069,0.008566356,0.00002169859,0.00001996258,0.0007669029,0.0003472915,0.07405413,0.9022321,0.00722703,0.006495394,0.00004574683],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9567479,0.001289811,0.0342361,0.001183417,0.00005760951,0.0000196125,0.0002721456,0.0002774364,0.005915887],"genre_scores_gemma":[0.9887661,0.0007149484,0.008675798,0.0002354846,0.0000163479,0.00001232018,0.0001642591,0.000042371,0.001372407],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002159006,"threshold_uncertainty_score":0.007222593,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02214291123870599,"score_gpt":0.26888186914,"score_spread":0.246738957901294,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}