{"id":"W2793647380","doi":"10.15252/emmm.201708483","title":"Human ALPI deficiency causes inflammatory bowel disease and highlights a key mechanism of gut homeostasis","year":2018,"lang":"en","type":"article","venue":"EMBO Molecular Medicine","topic":"Alkaline Phosphatase Research Studies","field":"Medicine","cited_by":63,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; University of Toronto; SickKids Foundation","funders":"National Heart, Lung, and Blood Institute; Fondation Princesse Grace de Monaco; Institut National de la Santé et de la Recherche Médicale; Fondation Maladies Rares; H2020 European Research Council; Agence Nationale de la Recherche; Canadian Institutes of Health Research; Leona M. and Harry B. Helmsley Charitable Trust","keywords":"Inflammatory bowel disease; Biology; Mutation; TLR2; Lipopolysaccharide; Immunology; Receptor; Genetics; Gene; Innate immune system; Disease; Medicine; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001122003,0.0006285234,0.0003360285,0.0004955912,0.0001677892,0.0003477646,0.0001935032,0.0004384515,0.0025501],"category_scores_gemma":[0.0002968631,0.0001187513,0.0002338137,0.0004062899,0.0003555584,0.0002255567,0.0003945316,0.0003960789,0.0005142508],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000143534,"about_ca_system_score_gemma":0.00009991755,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000290904,"about_ca_topic_score_gemma":0.000172427,"domain_scores_codex":[0.9998949,0.00002114611,0.0000136097,0.00002912797,0.0000263526,0.00001495019],"domain_scores_gemma":[0.9998599,0.00002795187,0.0000585838,0.00001120764,0.00001109805,0.00003119203],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001672508,0.00006279392,0.04193674,0.0006146007,0.0001313691,0.0256958,0.0002134465,0.0004816366,0.8930684,0.001913518,0.001190814,0.03301844],"study_design_scores_gemma":[0.0001899352,0.001057007,0.2106201,0.0002139394,0.0005051956,0.2305713,0.0006476733,0.003912002,0.496962,0.004286581,0.05096835,0.00006573813],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.978906,0.01103167,0.004990373,0.0008981746,0.00007912405,0.00002023109,0.0007107155,0.0001855427,0.003178033],"genre_scores_gemma":[0.9943878,0.002540783,0.001801917,0.0001035234,0.00004036508,0.000008333945,0.0003728283,0.00001665183,0.0007276986],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0025501,"threshold_uncertainty_score":0.008530915,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01711211891616856,"score_gpt":0.3087901168073199,"score_spread":0.2916779978911514,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}