{"id":"W2793647380","doi":"10.15252/emmm.201708483","title":"Human ALPI deficiency causes inflammatory bowel disease and highlights a key mechanism of gut homeostasis","year":2018,"lang":"en","type":"article","venue":"EMBO Molecular Medicine","topic":"Alkaline Phosphatase Research Studies","field":"Medicine","cited_by":63,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; University of Toronto; SickKids Foundation","funders":"National Heart, Lung, and Blood Institute; Fondation Princesse Grace de Monaco; Institut National de la Santé et de la Recherche Médicale; Fondation Maladies Rares; H2020 European Research Council; Agence Nationale de la Recherche; Canadian Institutes of Health Research; Leona M. and Harry B. Helmsley Charitable Trust","keywords":"Inflammatory bowel disease; Biology; Mutation; TLR2; Lipopolysaccharide; Immunology; Receptor; Genetics; Gene; Innate immune system; Disease; Medicine; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004676615,0.0003064018,0.000588269,0.0003543212,0.0002117654,0.000008160117,0.0001669643,0.00007640933,0.0002089359],"category_scores_gemma":[0.000787456,0.0002254204,0.00008408628,0.0003306979,0.001299258,0.00007414337,0.0002439267,0.0001895873,0.00002253543],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005827416,"about_ca_system_score_gemma":0.0001592633,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001769921,"about_ca_topic_score_gemma":0.00002591553,"domain_scores_codex":[0.9974374,0.00009092933,0.00050198,0.0004854931,0.001007552,0.0004766505],"domain_scores_gemma":[0.9980432,0.00006395033,0.0001603536,0.0006735224,0.0004660061,0.0005929748],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0008089184,0.0007673595,0.008303443,0.003212686,0.001270474,0.005214042,0.004877548,0.000001244675,0.7449586,0.2120127,0.01680161,0.001771298],"study_design_scores_gemma":[0.02471138,0.01366847,0.5003293,0.007070512,0.005234534,0.0003923085,0.003228067,0.0005895369,0.3781772,0.04420668,0.02022029,0.002171718],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9601948,0.03010407,0.0007781154,0.006151134,0.0001368948,0.0008069484,0.00004167205,0.00009846933,0.001687897],"genre_scores_gemma":[0.9968404,0.00144467,0.0003295053,0.0007372936,0.0003100408,0.00004154202,0.00005271646,0.00004601602,0.000197769],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4920258,"threshold_uncertainty_score":0.9192376,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01711211891616856,"score_gpt":0.3087901168073199,"score_spread":0.2916779978911514,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}