{"id":"W2793667162","doi":"10.1016/j.clcc.2018.02.010","title":"Gene Polymorphisms in the CCL5/CCR5 Pathway as a Genetic Biomarker for Outcome and Hand–Foot Skin Reaction in Metastatic Colorectal Cancer Patients Treated With Regorafenib","year":2018,"lang":"en","type":"article","venue":"Clinical Colorectal Cancer","topic":"Chemokine receptors and signaling","field":"Medicine","cited_by":31,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"M.S.I. Foundation; Japan Society for the Promotion of Science; National Cancer Institute; Krebsliga Schweiz; National Institutes of Health; Dhont Family Foundation","keywords":"Regorafenib; Medicine; Colorectal cancer; Cohort; CCL5; Internal medicine; Oncology; Single-nucleotide polymorphism; Hazard ratio; Biomarker; Genotype; Cancer; Immunology; Gene; Biology; Genetics; Confidence interval","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000718627,0.0003028863,0.0007370195,0.0001547389,0.0001174287,0.00004176886,0.000122029,0.0001969301,0.0001332864],"category_scores_gemma":[0.0003851411,0.0001909182,0.000153842,0.0005613846,0.0004609586,0.00007699564,0.00004088245,0.000335475,0.00000505667],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002783914,"about_ca_system_score_gemma":0.0003094159,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002109609,"about_ca_topic_score_gemma":0.007414603,"domain_scores_codex":[0.9975023,0.0002027187,0.0008799961,0.0006151508,0.0003353845,0.0004644492],"domain_scores_gemma":[0.9985575,0.0005921088,0.0002741292,0.0001724141,0.0002318806,0.0001719307],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.008370756,0.0006027787,0.949847,0.00004635869,0.000139759,0.00003334135,0.0004482876,0.000001932247,0.01236401,0.00000362345,0.0001938782,0.02794822],"study_design_scores_gemma":[0.009463049,0.004210973,0.9577909,0.0001996354,0.0002463995,0.000030519,0.00008053158,0.0008016973,0.02594246,0.000031497,0.0009217153,0.0002806336],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964986,0.0006170965,0.00001448572,0.0005855688,0.0003162032,0.001762593,0.00006828726,0.00002365414,0.0001134475],"genre_scores_gemma":[0.9976189,0.0001744642,0.0002540871,0.0005565827,0.0003592121,0.000827531,0.00005585658,0.00005103755,0.000102364],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02766758,"threshold_uncertainty_score":0.7785418,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05299488738616756,"score_gpt":0.3645735590039721,"score_spread":0.3115786716178046,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}