{"id":"W2793667162","doi":"10.1016/j.clcc.2018.02.010","title":"Gene Polymorphisms in the CCL5/CCR5 Pathway as a Genetic Biomarker for Outcome and Hand–Foot Skin Reaction in Metastatic Colorectal Cancer Patients Treated With Regorafenib","year":2018,"lang":"en","type":"article","venue":"Clinical Colorectal Cancer","topic":"Chemokine receptors and signaling","field":"Medicine","cited_by":31,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"M.S.I. Foundation; Japan Society for the Promotion of Science; National Cancer Institute; Krebsliga Schweiz; National Institutes of Health; Dhont Family Foundation","keywords":"Regorafenib; Medicine; Colorectal cancer; Cohort; CCL5; Internal medicine; Oncology; Single-nucleotide polymorphism; Hazard ratio; Biomarker; Genotype; Cancer; Immunology; Gene; Biology; Genetics; Confidence interval","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002085422,0.0002004992,0.0002600612,0.0002892444,0.0002037391,0.0003850556,0.0001364678,0.0002599306,0.001480367],"category_scores_gemma":[0.0006663615,0.00008696164,0.0003181493,0.0003583369,0.0001757248,0.0001412926,0.0001103389,0.0003652801,0.0001441325],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002677546,"about_ca_system_score_gemma":0.0001876576,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001482564,"about_ca_topic_score_gemma":0.001658766,"domain_scores_codex":[0.9998172,0.00005306879,0.00001629644,0.0000373045,0.00003542528,0.00004076305],"domain_scores_gemma":[0.9996775,0.00007492059,0.0001495668,0.00001683577,0.00002181719,0.00005932684],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002546004,0.0001093932,0.9831094,0.00002062626,0.0002174973,0.0004771854,0.0000462424,0.0002045801,0.006809889,0.00006941846,0.0001793915,0.006210341],"study_design_scores_gemma":[0.00003845277,0.0004238807,0.9966341,0.000005474496,0.0001320294,0.0008312101,0.00006737506,0.0005768094,0.0008868287,0.00005605119,0.0003424562,0.000005463205],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9992172,0.0002590892,0.00004932699,0.00003874106,0.000005124968,0.000002631569,0.00008609879,0.000002697955,0.0003390967],"genre_scores_gemma":[0.9996914,0.00004065318,0.00002743119,0.00001737354,0.000005039394,0.000001885499,0.0000782031,8.38137e-7,0.000137279],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001482564,"threshold_uncertainty_score":0.004952312,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05299488738616756,"score_gpt":0.3645735590039721,"score_spread":0.3115786716178046,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}