{"id":"W2793701389","doi":"10.1038/aps.2018.5","title":"Discovery and development of NA-1 for the treatment of acute ischemic stroke","year":2018,"lang":"en","type":"review","venue":"Acta Pharmacologica Sinica","topic":"S100 Proteins and Annexins","field":"Biochemistry, Genetics and Molecular Biology","cited_by":88,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto Western Hospital; University Health Network; Toronto Rehabilitation Institute; University of Toronto","funders":"","keywords":"Excitotoxicity; Neuroprotection; Stroke (engine); Medicine; Oxidative stress; Glutamate receptor; Neuroscience; Bench to bedside; Inflammation; Pathophysiology; Pharmacology; Acute stroke; Bioinformatics; Internal medicine; Tissue plasminogen activator; Biology; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003342521,0.0005916043,0.0008727791,0.002143549,0.0002665978,0.0006733221,0.000598743,0.0008815919,0.003389762],"category_scores_gemma":[0.0004019496,0.0002111458,0.0004180514,0.00124099,0.0003811887,0.0009751953,0.0006014056,0.002011683,0.002097906],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004094511,"about_ca_system_score_gemma":0.0007518604,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006173836,"about_ca_topic_score_gemma":0.001294626,"domain_scores_codex":[0.9998913,0.00001457009,0.00001732216,0.00001902394,0.00004538849,0.00001235777],"domain_scores_gemma":[0.9998984,0.00003545263,0.00001572118,0.000004333665,0.0000326037,0.00001332551],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00009259355,0.0001154469,0.0001387692,0.01152971,0.00008824307,0.0003232723,0.00007326254,0.0002772377,0.00563862,0.006315082,0.01806868,0.957339],"study_design_scores_gemma":[0.00002889663,0.0001292865,0.0005145789,0.001748908,0.00008319512,0.001380412,0.00004603879,0.00008149102,0.001507545,0.0021955,0.9922686,0.00001569075],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0003028824,0.9975086,0.0002435338,0.0002786989,0.0002117063,0.000009082724,0.00002372512,0.00001098673,0.001410772],"genre_scores_gemma":[0.001255484,0.997396,0.000294328,0.000161847,0.00009647253,0.000008800857,0.00002985349,0.000001935498,0.0007553334],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003389762,"threshold_uncertainty_score":0.0113399,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06990469967538702,"score_gpt":0.3793091746695185,"score_spread":0.3094044749941314,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}