{"id":"W2793739849","doi":"10.3390/ijms19030860","title":"Some Metabolites Act as Second Messengers in Yeast Chronological Aging","year":2018,"lang":"en","type":"review","venue":"International Journal of Molecular Sciences","topic":"Fungal and yeast genetics research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"Concordia University","funders":"Natural Sciences and Engineering Research Council of Canada; Concordia University","keywords":"Yeast; Second messenger system; Saccharomyces cerevisiae; Biochemistry; Biology; Trehalose; Signal transduction; Cell biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004846899,0.0009240012,0.0008606793,0.00235166,0.0003704706,0.0009558107,0.000866783,0.001338891,0.001780343],"category_scores_gemma":[0.0005004701,0.0003013728,0.0003595633,0.002181438,0.0006578758,0.001589716,0.0007178211,0.001581903,0.001933971],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007217017,"about_ca_system_score_gemma":0.0007743901,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009186994,"about_ca_topic_score_gemma":0.001189432,"domain_scores_codex":[0.99986,0.00001781099,0.00002329225,0.00003689626,0.00004700841,0.00001503705],"domain_scores_gemma":[0.9997255,0.0001070244,0.00004172621,0.00001096169,0.00008194448,0.00003274285],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00009337316,0.00006926522,0.0002626546,0.01173059,0.00006304588,0.0004511872,0.0001125493,0.0005779551,0.01026427,0.008695887,0.01349578,0.9541834],"study_design_scores_gemma":[0.000008404837,0.00008136531,0.0006497503,0.001031073,0.00006203491,0.001360351,0.00005379099,0.00008389722,0.003857061,0.002054874,0.9907369,0.00002068563],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002070973,0.9976042,0.0004239275,0.0001705146,0.000222505,0.000004851061,0.00001715282,0.00001224165,0.001337546],"genre_scores_gemma":[0.001574626,0.9966222,0.0004960081,0.0001642406,0.00014352,0.00000886597,0.00003616365,0.000002994456,0.0009512841],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.00235166,"threshold_uncertainty_score":0.005955815,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03879078065162869,"score_gpt":0.3799447318667534,"score_spread":0.3411539512151247,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}