{"id":"W2793752308","doi":"10.1200/jco.2018.36.4_suppl.349","title":"The Canadian Cancer Trials Group PA.7 trial: Results from the safety run in of a randomized phase II study of gemcitabine (GEM) and nab-paclitaxel (Nab-P) versus GEM, nab-P, durvalumab (D), and tremelimumab (T) as first-line therapy in metastatic pancreatic ductal adenocarcinoma (mPDAC).","year":2018,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Pancreatic and Hepatic Oncology Research","field":"Medicine","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University; University of Toronto; BC Cancer Agency; Princess Margaret Cancer Centre; Ottawa Hospital; University of Calgary; McGill University; Jewish General Hospital; University of Ottawa","funders":"","keywords":"Medicine; Gemcitabine; Internal medicine; Clinical endpoint; Oncology; Adjuvant; Cancer; Randomized controlled trial; Gastroenterology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002747906,0.002293587,0.002528518,0.0004990898,0.001399136,0.001108853,0.00167659,0.001694719,0.009976267],"category_scores_gemma":[0.0034455,0.0005815679,0.002376917,0.0009228017,0.0014331,0.0006532818,0.0005331158,0.003177748,0.001010234],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.008270053,"about_ca_system_score_gemma":0.02288674,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.1807104,"about_ca_topic_score_gemma":0.4025832,"domain_scores_codex":[0.9985504,0.000803587,0.00003978122,0.0001713233,0.0002341828,0.0002007954],"domain_scores_gemma":[0.9983706,0.0002846665,0.0003031693,0.00009989351,0.0002101772,0.0007316166],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9232913,0.003686978,0.002552744,0.001290918,0.002469718,0.0001118249,0.0001117517,0.001043189,0.001744525,0.0008750565,0.03226276,0.03055926],"study_design_scores_gemma":[0.9581543,0.02287587,0.007203348,0.00009886936,0.001476683,0.00008935467,0.00004731731,0.0007177543,0.0002906611,0.0003559405,0.008643003,0.00004686096],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8713426,0.02733272,0.001490231,0.01052171,0.001730454,0.01924866,0.03483991,0.0005285508,0.03296525],"genre_scores_gemma":[0.8954924,0.01246339,0.008189662,0.007782833,0.001047342,0.0219438,0.02795335,0.0002019958,0.02492522],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1807104,"threshold_uncertainty_score":0.3593171,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2672946897511326,"score_gpt":0.5241850064502284,"score_spread":0.2568903166990957,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}