{"id":"W2793778397","doi":"10.3390/pathogens7010020","title":"The Structure of PrPSc Prions","year":2018,"lang":"en","type":"review","venue":"Pathogens","topic":"Prion Diseases and Protein Misfolding","field":"Biochemistry, Genetics and Molecular Biology","cited_by":85,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Alberta Prion Research Institute; Alberta Livestock and Meat Agency; European Commission","keywords":"Scrapie; Chronic wasting disease; Bovine spongiform encephalopathy; Prion protein; Gene isoform; Kuru; Chemistry; Biology; Virology; Cell biology; Disease; Biochemistry; Pathology; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001084538,0.0002010303,0.000352479,0.00002185943,0.0001371285,0.00001891727,0.0003868206,0.0002463142,0.00003669894],"category_scores_gemma":[0.0001520715,0.0001226908,0.0004251654,0.00008591493,0.000101195,6.066606e-7,0.000191654,0.00009452618,0.000009512136],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00000814032,"about_ca_system_score_gemma":0.0002196993,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00000112212,"about_ca_topic_score_gemma":0.000007825973,"domain_scores_codex":[0.9990347,0.0001144131,0.0002880288,0.0002694778,0.0001013574,0.0001920169],"domain_scores_gemma":[0.9989641,0.00002566449,0.0002543446,0.0006216465,0.00006965989,0.00006453871],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000004757494,0.000008600013,0.000003337931,0.001361717,0.0001396011,0.000001151798,0.000005141195,1.537854e-7,0.003103109,0.00009528743,0.001749564,0.9935276],"study_design_scores_gemma":[0.00003533706,0.00005064821,0.000002272312,0.0005793225,0.0002117072,0.00001386798,0.000003697289,3.376939e-7,0.0007286523,0.00006186434,0.99817,0.0001422706],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00009653581,0.9985617,0.00004149872,0.000005545525,0.0001867387,0.0003697374,0.0006001964,0.00000509452,0.0001329708],"genre_scores_gemma":[0.0001674475,0.9986609,0.0002116438,0.00001445423,0.000462404,0.00001393286,0.0002562141,0.00003185945,0.0001811142],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9964204,"threshold_uncertainty_score":0.5003187,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01981737689342658,"score_gpt":0.3090950747564323,"score_spread":0.2892776978630057,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}