{"id":"W2793778397","doi":"10.3390/pathogens7010020","title":"The Structure of PrPSc Prions","year":2018,"lang":"en","type":"review","venue":"Pathogens","topic":"Prion Diseases and Protein Misfolding","field":"Biochemistry, Genetics and Molecular Biology","cited_by":85,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Alberta Prion Research Institute; Alberta Livestock and Meat Agency; European Commission","keywords":"Scrapie; Chronic wasting disease; Bovine spongiform encephalopathy; Prion protein; Gene isoform; Kuru; Chemistry; Biology; Virology; Cell biology; Disease; Biochemistry; Pathology; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003564913,0.0007140168,0.0008594209,0.00178798,0.0003155927,0.0008689181,0.0006810124,0.0008731468,0.002054022],"category_scores_gemma":[0.0005026897,0.0002610168,0.000282277,0.00164102,0.0005453923,0.001181779,0.0006052969,0.001567195,0.002267844],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006300636,"about_ca_system_score_gemma":0.001001766,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001176307,"about_ca_topic_score_gemma":0.001023922,"domain_scores_codex":[0.9998615,0.00001827344,0.00001845211,0.00002801591,0.00005840371,0.00001533643],"domain_scores_gemma":[0.9998484,0.00004822792,0.00002501693,0.000007194343,0.00005222475,0.00001900384],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00006702341,0.00004826581,0.0002371763,0.0180103,0.00005282643,0.0003028267,0.0001127627,0.0005066264,0.006203517,0.01058643,0.03261611,0.9312561],"study_design_scores_gemma":[0.000004323531,0.00003445546,0.0004574543,0.001422061,0.00003074297,0.0007799614,0.00002901726,0.00006080825,0.0009259842,0.002324464,0.9939176,0.00001308241],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002113147,0.9972039,0.0002179199,0.0002562669,0.0002450758,0.000006164249,0.00003353981,0.00001151168,0.001814205],"genre_scores_gemma":[0.001104463,0.9975019,0.0001892844,0.0001133834,0.0001602064,0.000006264961,0.00005106541,0.000001718006,0.0008716518],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002054022,"threshold_uncertainty_score":0.006871462,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01981737689342658,"score_gpt":0.3090950747564323,"score_spread":0.2892776978630057,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}