{"id":"W2793779891","doi":"10.1073/pnas.1720871115","title":"Expansions, diversification, and interindividual copy number variations of AID/APOBEC family cytidine deaminase genes in lampreys","year":2018,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Aquaculture disease management and microbiota","field":"Immunology and Microbiology","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"Memorial University of Newfoundland","funders":"FP7 Ideas: European Research Council; Institut National de la Recherche Agronomique; U.S. National Library of Medicine; Deutsche Forschungsgemeinschaft; Max-Planck-Gesellschaft; Canadian Cancer Society; Canadian HIV Trials Network, Canadian Institutes of Health Research; Canadian Institutes of Health Research; Canadian Network for Research and Innovation in Machining Technology, Natural Sciences and Engineering Research Council of Canada","keywords":"APOBEC; Cytidine deaminase; Biology; Genetics; Cytidine; Gene; Activation-induced (cytidine) deaminase; Somatic hypermutation; Genome; Biochemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001192904,0.00008981601,0.0001647755,0.001151596,0.0001727301,0.0002695439,0.00009428847,0.0001741107,0.000609686],"category_scores_gemma":[0.0002888848,0.0001220505,0.0001381622,0.0004533277,0.0002355864,0.0001312883,0.0001955165,0.0001400448,0.0001812601],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002632735,"about_ca_system_score_gemma":0.00008416537,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002163401,"about_ca_topic_score_gemma":0.00356116,"domain_scores_codex":[0.9998887,0.0000129132,0.000009700363,0.0000470564,0.00002086119,0.00002089248],"domain_scores_gemma":[0.9997481,0.00005837375,0.00008387666,0.000025819,0.0000414221,0.00004236971],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0004736398,0.00002511871,0.3021416,0.00005920236,0.00008952701,0.0001662198,0.0009821963,0.0002436348,0.6813924,0.0001097137,0.00008203732,0.01423476],"study_design_scores_gemma":[0.000001873099,0.00004464119,0.9926531,0.000003272921,0.00003041287,0.0002724998,0.0001973362,0.0002172811,0.006079325,0.0000298109,0.0004634766,0.000006886323],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9992887,0.0001225899,0.00009261892,0.000003176017,7.254754e-7,0.000001636555,0.0001923369,0.000004117839,0.0002941347],"genre_scores_gemma":[0.9991391,0.00005759061,0.0002231566,0.000005940618,0.000001454562,0.00000354894,0.0002269957,0.000003368433,0.0003390085],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002163401,"threshold_uncertainty_score":0.004301608,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03091206168040461,"score_gpt":0.2889087524640803,"score_spread":0.2579966907836757,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}