{"id":"W2793881818","doi":"10.1165/rcmb.2017-0413oc","title":"TRPV4 Stimulation Releases ATP via Pannexin Channels in Human Pulmonary Fibroblasts","year":2018,"lang":"en","type":"article","venue":"American Journal of Respiratory Cell and Molecular Biology","topic":"Connexins and lens biology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"Canadian Institutes of Health Research","keywords":"PPADS; Pannexin; Purinergic receptor; Carbenoxolone; P2 receptor; Channel blocker; Flufenamic acid; TRPV4; Chemistry; Apyrase; Transient receptor potential channel; Niflumic acid; Biophysics; Extracellular; Cell biology; Connexin; Gap junction; Pharmacology; Biochemistry; Intracellular; Receptor; Biology; Calcium","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001671044,0.0002092652,0.000282221,0.0001080751,0.0001051884,0.0002260472,0.0001054134,0.0002505288,0.0008795672],"category_scores_gemma":[0.0001483501,0.0000851048,0.0002497463,0.0001307151,0.0001309988,0.000200582,0.0001947273,0.0004069137,0.0002970652],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001422855,"about_ca_system_score_gemma":0.00009893814,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005691845,"about_ca_topic_score_gemma":0.0004598616,"domain_scores_codex":[0.9998176,0.00003535968,0.00002427703,0.00003968172,0.00005088915,0.0000322238],"domain_scores_gemma":[0.999929,0.00002025899,0.00001501548,0.00001281321,0.000008855511,0.00001410068],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006362586,0.00001005058,0.00008528367,0.00002315342,0.000001933687,0.00008775137,0.00001375006,0.00002070681,0.9991835,0.00002269457,0.00001580772,0.0004718021],"study_design_scores_gemma":[0.00002833866,0.0003334859,0.004101199,0.000004276238,0.00001223928,0.0004555564,0.00005604963,0.0007932542,0.9922287,0.00003287329,0.001949094,0.000004909824],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9913372,0.001997159,0.004611684,0.000112217,0.000051482,0.00003912072,0.000418977,0.00008476234,0.001347279],"genre_scores_gemma":[0.99651,0.0005477731,0.001438831,0.00005817059,0.00001283466,0.0000354441,0.0002537172,0.000007526251,0.001135721],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008795672,"threshold_uncertainty_score":0.002942383,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007933460036259115,"score_gpt":0.2668532238384536,"score_spread":0.2589197638021945,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}