{"id":"W2793941776","doi":"10.1111/hae.13413","title":"Recombinant factor VIII Fc fusion protein for immune tolerance induction in patients with severe haemophilia A with inhibitors—A retrospective analysis","year":2018,"lang":"en","type":"article","venue":"Haemophilia","topic":"Hemophilia Treatment and Research","field":"Medicine","cited_by":40,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta; Institute for Clinical Evaluative Sciences; SickKids Foundation; Stollery Children's Hospital; Hospital for Sick Children","funders":"Daiichi Sankyo Europe; Novo Nordisk; Grifols; Bayer HealthCare; Genentech; PTC Therapeutics; Baxalta; CSL Behring; Biogen; Pfizer","keywords":"Medicine; Haemophilia; Haemophilia A; Retrospective cohort study; Adverse effect; Internal medicine; Titer; Haemophilia B; Surgery; Immunology; Antibody","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002783164,0.0004414496,0.0009168677,0.0007263052,0.0003016719,0.00004636797,0.0001570984,0.0002586882,0.0002079723],"category_scores_gemma":[0.0001029103,0.0002874171,0.0002014056,0.002177729,0.0002941209,0.000296853,0.00006949342,0.000427917,0.00004773832],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006255321,"about_ca_system_score_gemma":0.0002095762,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000175041,"about_ca_topic_score_gemma":0.0004270523,"domain_scores_codex":[0.9969406,0.00008580526,0.0005175855,0.0009057263,0.0008468985,0.0007034075],"domain_scores_gemma":[0.9979193,0.00003428784,0.0002263597,0.0007092354,0.0008757578,0.0002351114],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01097732,0.001583446,0.9748759,0.0001733528,0.0008021398,0.0000597557,0.0009998694,0.000009426089,0.003217333,0.00003538376,0.0002311479,0.007034962],"study_design_scores_gemma":[0.01059523,0.009571806,0.9630021,0.0006467613,0.0003778575,0.0000138278,0.00009712442,0.0002245506,0.0146049,0.000127593,0.0003101163,0.000428181],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9939299,0.00005690287,0.00007554722,0.0009532294,0.0001825324,0.004262018,0.00007190623,0.00008686288,0.000381156],"genre_scores_gemma":[0.995023,0.00001123737,0.001380455,0.00004197836,0.0003065431,0.0003669693,0.0002862599,0.00007028172,0.002513242],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01187381,"threshold_uncertainty_score":0.9999578,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01436934826593615,"score_gpt":0.263162607402028,"score_spread":0.2487932591360919,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}