{"id":"W2793941776","doi":"10.1111/hae.13413","title":"Recombinant factor VIII Fc fusion protein for immune tolerance induction in patients with severe haemophilia A with inhibitors—A retrospective analysis","year":2018,"lang":"en","type":"article","venue":"Haemophilia","topic":"Hemophilia Treatment and Research","field":"Medicine","cited_by":40,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta; Institute for Clinical Evaluative Sciences; SickKids Foundation; Stollery Children's Hospital; Hospital for Sick Children","funders":"Daiichi Sankyo Europe; Novo Nordisk; Grifols; Bayer HealthCare; Genentech; PTC Therapeutics; Baxalta; CSL Behring; Biogen; Pfizer","keywords":"Medicine; Haemophilia; Haemophilia A; Retrospective cohort study; Adverse effect; Internal medicine; Titer; Haemophilia B; Surgery; Immunology; Antibody","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009716187,0.0002440545,0.0005637255,0.001171228,0.0002253903,0.0006272359,0.0003539803,0.000409417,0.001038229],"category_scores_gemma":[0.003402079,0.0002451976,0.001233352,0.002293505,0.0002467784,0.0004428525,0.0002614225,0.0003221999,0.0002195658],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003720828,"about_ca_system_score_gemma":0.0005069683,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001252425,"about_ca_topic_score_gemma":0.0008894327,"domain_scores_codex":[0.9989071,0.0002076022,0.0003062038,0.0002698433,0.0002372038,0.00007210559],"domain_scores_gemma":[0.996534,0.0009997832,0.00179389,0.0001839724,0.0003395407,0.0001487846],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.000452542,0.0000294354,0.988589,0.0005639135,0.0007304766,0.001326859,0.00007515783,0.00004499012,0.0002900566,0.00003777385,0.0003931797,0.007466507],"study_design_scores_gemma":[0.00009987356,0.0007072525,0.9775484,0.000389477,0.001427859,0.01640967,0.000268849,0.000178376,0.0003657165,0.00004242874,0.002541964,0.00002017464],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9586207,0.03934634,0.0002819287,0.00009339828,0.00002620325,0.00005590624,0.0008706462,0.00000719488,0.0006976913],"genre_scores_gemma":[0.9925613,0.006317255,0.0001286024,0.00007231055,0.00002972692,0.0000215833,0.0007793064,0.000004173282,0.00008583374],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001252425,"threshold_uncertainty_score":0.005138457,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01436934826593615,"score_gpt":0.263162607402028,"score_spread":0.2487932591360919,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}