{"id":"W2793967558","doi":"10.1016/j.stemcr.2018.02.007","title":"KLF4 Nuclear Export Requires ERK Activation and Initiates Exit from Naive Pluripotency","year":2018,"lang":"en","type":"article","venue":"Stem Cell Reports","topic":"Kruppel-like factors research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":57,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research; Canada Foundation for Innovation","keywords":"Biology; KLF4; MAPK/ERK pathway; Cell biology; Nuclear export signal; SOX2; Genetics; Kinase; Cell nucleus; Gene; Transcription factor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001145634,0.0002270191,0.0001819246,0.0001403307,0.0001221005,0.0002956818,0.000176716,0.0001475191,0.001125076],"category_scores_gemma":[0.0001348714,0.0001348963,0.0002572577,0.00008435766,0.0001944474,0.0002992506,0.0002177702,0.0003557217,0.0005438625],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003296175,"about_ca_system_score_gemma":0.0002671775,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006091897,"about_ca_topic_score_gemma":0.0008477754,"domain_scores_codex":[0.9999169,0.000009672942,0.00001004763,0.00001577752,0.00002052462,0.00002717411],"domain_scores_gemma":[0.9999086,0.00001106324,0.00002076985,0.00001397117,0.00001787203,0.00002771941],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002182807,0.00002113446,0.001186536,0.00002427294,0.000004109056,0.000142205,0.00001515434,0.0001060697,0.9961612,0.0003740916,0.00003863761,0.001708184],"study_design_scores_gemma":[0.00002453674,0.0001416882,0.01168545,0.000004941857,0.000008282126,0.0004674127,0.00003945081,0.001178307,0.9842678,0.0002634007,0.00191288,0.000005804202],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9951426,0.0003439478,0.002776978,0.00004392635,0.000008854606,0.000007572908,0.0001665469,0.0000972804,0.001412285],"genre_scores_gemma":[0.9945791,0.0002646747,0.001573466,0.00003457229,0.00000446219,0.00001074918,0.0005570357,0.00002816501,0.002947803],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001125076,"threshold_uncertainty_score":0.003763735,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01666475150002068,"score_gpt":0.2597475184683791,"score_spread":0.2430827669683584,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}