{"id":"W2793970618","doi":"10.1016/j.biopsych.2018.01.017","title":"Opposite Molecular Signatures of Depression in Men and Women","year":2018,"lang":"en","type":"review","venue":"Biological Psychiatry","topic":"Tryptophan and brain disorders","field":"Neuroscience","cited_by":285,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; Centre for Addiction and Mental Health","funders":"National Institute of Mental Health","keywords":"Major depressive disorder; Anterior cingulate cortex; Prefrontal cortex; Dorsolateral prefrontal cortex; Depression (economics); Psychology; Gene; Internal medicine; Amygdala; Clinical psychology; Endocrinology; Neuroscience; Medicine; Biology; Genetics; Cognition","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003797935,0.0004230502,0.0009232272,0.0007363819,0.0001103698,0.0008463484,0.0005027099,0.0007694169,0.001592295],"category_scores_gemma":[0.0008508105,0.0001372398,0.0004290544,0.0007623683,0.0004145178,0.0006275824,0.0005193091,0.0008951967,0.0004476738],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002929594,"about_ca_system_score_gemma":0.0006635221,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001256065,"about_ca_topic_score_gemma":0.002058948,"domain_scores_codex":[0.9998778,0.00002053132,0.00002176219,0.00003841125,0.00002695267,0.0000144325],"domain_scores_gemma":[0.9997775,0.0001266496,0.00003510255,0.00000738529,0.00004070246,0.00001251638],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002830719,0.00002515518,0.00237558,0.009662148,0.0003744869,0.000424981,0.00009605227,0.0001978372,0.00199912,0.003503351,0.01647149,0.9645867],"study_design_scores_gemma":[0.00009258259,0.000177731,0.0263309,0.01083717,0.001356943,0.006437504,0.0003667092,0.0002213379,0.001288617,0.01138417,0.9414215,0.00008484674],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.000425151,0.9982926,0.0001163782,0.00043772,0.0001545926,0.000002026633,0.00004105244,0.00000445455,0.0005259954],"genre_scores_gemma":[0.003858319,0.9945719,0.0002451863,0.0004723323,0.0003478368,0.00000458998,0.00007671102,0.00000199518,0.0004211123],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001592295,"threshold_uncertainty_score":0.005326807,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04373178597940929,"score_gpt":0.3216719071036338,"score_spread":0.2779401211242245,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}