{"id":"W2793978097","doi":"10.1111/febs.14408","title":"The structure of the apo <scp>cAMP</scp>‐binding domain of <scp>HCN</scp>4 – a stepping stone toward understanding the <scp>cAMP</scp>‐dependent modulation of the hyperpolarization‐activated cyclic‐nucleotide‐gated ion channels","year":2018,"lang":"en","type":"review","venue":"FEBS Journal","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"HCN channel; Allosteric regulation; Chemistry; Biophysics; Hyperpolarization (physics); Ion channel; Gene isoform; Stereochemistry; Cell biology; Biochemistry; Receptor; Nuclear magnetic resonance spectroscopy; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","sts"],"consensus_categories":[],"category_scores_codex":[0.001707678,0.0006884696,0.001012436,0.0002866869,0.001364823,0.0002174756,0.001254172,0.0008980779,0.00001232155],"category_scores_gemma":[0.001879496,0.0003614812,0.0009741843,0.001103947,0.0005155132,0.00005638238,0.0004677423,0.00110166,0.000003498874],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003383862,"about_ca_system_score_gemma":0.0005013436,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001398716,"about_ca_topic_score_gemma":0.00001598878,"domain_scores_codex":[0.9945168,0.001414197,0.001676613,0.0005789434,0.00117195,0.000641506],"domain_scores_gemma":[0.9933689,0.0006214847,0.004191567,0.0009539889,0.0007196327,0.0001444061],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00008397446,0.000418753,0.001148231,0.004501551,0.00540154,0.000006575352,0.01058977,0.02017201,0.929091,0.002682027,0.009601625,0.01630289],"study_design_scores_gemma":[0.006382533,0.001432947,0.003303202,0.01945134,0.00385232,0.001855431,0.03235626,0.005365306,0.3559643,0.009835623,0.5594823,0.0007184942],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6950685,0.2483488,0.03796149,0.0002669945,0.01239521,0.004567189,0.0005406065,0.00006296345,0.0007882608],"genre_scores_gemma":[0.8412188,0.1546895,0.0001164891,0.00006992328,0.002233114,0.00001677111,0.0003171708,0.0001676445,0.001170655],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5731267,"threshold_uncertainty_score":0.9999353,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03437910694502833,"score_gpt":0.2688766494756276,"score_spread":0.2344975425305993,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}