{"id":"W2793994644","doi":"10.1016/j.ymthe.2018.03.015","title":"Amelioration of Neurosensory Structure and Function in Animal and Cellular Models of a Congenital Blindness","year":2018,"lang":"en","type":"article","venue":"Molecular Therapy","topic":"Retinal Development and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":27,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University Health Centre","funders":"Canadian Institutes of Health Research; National Institutes of Health; Paul MacKall and Evanina Bell MacKall Trust; National Eye Institute; James N. Kirby Foundation; University of Pennsylvania; Research to Prevent Blindness; F. M. Kirby Foundation; Foundation Fighting Blindness","keywords":"Ciliopathy; Biology; Genetic enhancement; Ciliopathies; Retinal; Electroretinography; Cilium; Ophthalmology; Retina; Retinal degeneration; Retinal Disorder; Cell biology; Gene; Neuroscience; Medicine; Genetics; Phenotype","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003554834,0.0005525316,0.000346778,0.00089715,0.0003918329,0.000447012,0.000432861,0.0007078109,0.002311072],"category_scores_gemma":[0.0002320359,0.0001938788,0.000312087,0.0002731736,0.0007358491,0.0003859578,0.0002756132,0.0008846367,0.000230013],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002897796,"about_ca_system_score_gemma":0.0005232914,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009160587,"about_ca_topic_score_gemma":0.001021973,"domain_scores_codex":[0.9997844,0.00004491578,0.00001898461,0.00002655214,0.00006727589,0.00005801906],"domain_scores_gemma":[0.9997808,0.00004088226,0.00005741564,0.00003278184,0.00002037588,0.0000676548],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005372163,0.0001769576,0.0001300447,0.00008915211,0.00001702123,0.0002594251,0.00003397643,0.0001914507,0.9926583,0.001347245,0.0001367543,0.004422398],"study_design_scores_gemma":[0.0001020538,0.001556645,0.002257236,0.00001775422,0.00006556892,0.0008116534,0.0000648209,0.0009387622,0.9909596,0.0005709842,0.002642572,0.00001229784],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9879285,0.003532198,0.00487078,0.0003629802,0.00009386741,0.00005180282,0.0001851085,0.0002700203,0.00270481],"genre_scores_gemma":[0.9928565,0.001845423,0.001677181,0.00004985696,0.00001681711,0.00003549475,0.000126417,0.00002683128,0.003365342],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002311072,"threshold_uncertainty_score":0.007731318,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009589029443815848,"score_gpt":0.2201258214252127,"score_spread":0.2105367919813969,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}