{"id":"W2794024987","doi":"10.1152/ajpgi.00027.2018","title":"Protective effects of guggulsterone against colitis are associated with the suppression of TREM-1 and modulation of macrophages","year":2018,"lang":"en","type":"article","venue":"American Journal of Physiology-Gastrointestinal and Liver Physiology","topic":"Inflammation biomarkers and pathways","field":"Immunology and Microbiology","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Yonsei University College of Medicine; Korea Research Institute of Bioscience and Biotechnology; National Research Foundation of Korea; Korea Health Industry Development Institute; Yonsei University; Ministry of Science, ICT and Future Planning; Korean Society of Gastroenterology; National Research Foundation","keywords":"Colitis; Inflammatory bowel disease; TLR4; Cancer research; Receptor; Myeloid; Toll-like receptor; Inflammation; Signal transduction; Chemistry; Immunology; Pharmacology; Biology; Medicine; Cell biology; Innate immune system; Internal medicine; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009060044,0.0004852536,0.0003710247,0.0002681012,0.0001016276,0.0001123402,0.0001307164,0.0002410321,0.0009004625],"category_scores_gemma":[0.0001064733,0.000102746,0.0002494898,0.0001230339,0.0002331432,0.0001350065,0.0001434065,0.0004622811,0.0001735706],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007869727,"about_ca_system_score_gemma":0.0001413801,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001778294,"about_ca_topic_score_gemma":0.0003773063,"domain_scores_codex":[0.9999357,0.0000184784,0.000009916975,0.000009030688,0.000007833266,0.00001894563],"domain_scores_gemma":[0.9999312,0.000008337181,0.00002255675,0.000006693602,0.000006251929,0.00002505033],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001786799,0.0001199059,0.0002626809,0.0001702232,0.00001612455,0.0001648951,0.00001528924,0.00005108144,0.9929102,0.000030351,0.00005680515,0.004415634],"study_design_scores_gemma":[0.0005729236,0.009616611,0.02379663,0.00003623041,0.0001474602,0.0009430378,0.00007594259,0.0004438691,0.9611963,0.0001202248,0.00303506,0.00001565419],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9944516,0.003844552,0.0006122829,0.00009710916,0.00004063724,0.00002947751,0.0002156543,0.00007397913,0.0006347483],"genre_scores_gemma":[0.9951662,0.002726401,0.0007284175,0.0001037557,0.00002343615,0.00004052401,0.0002610536,0.000007730816,0.000942397],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009004625,"threshold_uncertainty_score":0.003012419,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004701146812092775,"score_gpt":0.1908862752616606,"score_spread":0.1861851284495679,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}