{"id":"W2794066541","doi":"10.1002/cmdc.201700718","title":"Discovery of Rogaratinib (BAY 1163877): a pan‐FGFR Inhibitor","year":2018,"lang":"en","type":"article","venue":"ChemMedChem","topic":"Fibroblast Growth Factor Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":62,"is_retracted":false,"has_abstract":true,"ca_institutions":"Discovery Centre","funders":"","keywords":"Fibroblast growth factor receptor; Fibroblast growth factor receptor 1; Bay; Pharmacokinetics; Drug discovery; Small molecule; Cancer research; Fibroblast growth factor; Chemistry; Pharmacology; Receptor; Computational biology; Medicine; Biology; Biochemistry; Geography","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004073835,0.0007912861,0.0007712058,0.0005196817,0.0001846651,0.0007176125,0.0008798611,0.0005816926,0.001483612],"category_scores_gemma":[0.0002990308,0.0002775749,0.000514365,0.0003837345,0.0003291809,0.0004956293,0.0004992528,0.0009171749,0.00109579],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008185254,"about_ca_system_score_gemma":0.0008804771,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006775738,"about_ca_topic_score_gemma":0.001580933,"domain_scores_codex":[0.9996971,0.0000445121,0.00002038031,0.00005422826,0.000111115,0.00007275329],"domain_scores_gemma":[0.9999288,0.000005413002,0.00001679119,0.000006387187,0.00001553813,0.00002708688],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007331039,0.0004420425,0.0006841658,0.0004857879,0.0001185331,0.0009797042,0.0000776291,0.005527996,0.894899,0.002645697,0.002435692,0.09097061],"study_design_scores_gemma":[0.002290275,0.008984231,0.002997088,0.00004941838,0.0002941858,0.005432838,0.00005318039,0.008653566,0.9145465,0.0007438943,0.05586338,0.00009158468],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9294782,0.01695321,0.02831618,0.002254678,0.000274168,0.001346793,0.002953685,0.0008991361,0.01752399],"genre_scores_gemma":[0.9590949,0.009031524,0.02109076,0.0003982082,0.00005503438,0.0001852788,0.003600169,0.00006964699,0.006474443],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001483612,"threshold_uncertainty_score":0.005938828,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01528207215363338,"score_gpt":0.2823117751963115,"score_spread":0.2670297030426781,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}