{"id":"W2794066541","doi":"10.1002/cmdc.201700718","title":"Discovery of Rogaratinib (BAY 1163877): a pan‐FGFR Inhibitor","year":2018,"lang":"en","type":"article","venue":"ChemMedChem","topic":"Fibroblast Growth Factor Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":62,"is_retracted":false,"has_abstract":true,"ca_institutions":"Discovery Centre","funders":"","keywords":"Fibroblast growth factor receptor; Fibroblast growth factor receptor 1; Bay; Pharmacokinetics; Drug discovery; Small molecule; Cancer research; Fibroblast growth factor; Chemistry; Pharmacology; Receptor; Computational biology; Medicine; Biology; Biochemistry; Geography","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001736399,0.0001849168,0.0001967325,0.00004843819,0.00005335232,0.00002791953,0.0003197349,0.0001960754,0.00006344071],"category_scores_gemma":[0.0002403339,0.000169252,0.0001240372,0.0001625666,0.0004377607,0.00001117942,0.0002901909,0.0001235737,0.00008108264],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002073048,"about_ca_system_score_gemma":0.0001389649,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001317864,"about_ca_topic_score_gemma":0.00002571377,"domain_scores_codex":[0.9986551,0.00003630899,0.0002631504,0.0004068823,0.0002613051,0.0003772005],"domain_scores_gemma":[0.9990403,0.0000225716,0.0000948926,0.0005683812,0.0001820059,0.0000918498],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000138684,0.00008319803,0.002467663,0.00005349458,0.00004453217,0.000001789024,0.00008088975,1.363886e-7,0.9877849,0.00007668992,0.008601193,0.0006668699],"study_design_scores_gemma":[0.0005374106,0.0004646826,0.002020337,0.00003160771,0.000007665498,0.000007326869,0.00006732567,0.00000965971,0.9849759,0.00005778652,0.01164035,0.0001799876],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.992722,0.0001751031,0.0003062942,0.0001265922,0.0001476595,0.0001869629,0.00003604186,0.00001637532,0.006283008],"genre_scores_gemma":[0.9956243,0.00001940844,0.0005893285,0.00008906393,0.0008432312,0.00002391573,0.00009082387,0.00003745431,0.002682485],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003600523,"threshold_uncertainty_score":0.6901895,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01528207215363338,"score_gpt":0.2823117751963115,"score_spread":0.2670297030426781,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}