{"id":"W2794070712","doi":"10.1194/jlr.m081851","title":"Small molecule inducers of ABCA1 and apoE that act through indirect activation of the LXR pathway","year":2018,"lang":"en","type":"article","venue":"Journal of Lipid Research","topic":"Cholesterol and Lipid Metabolism","field":"Medicine","cited_by":48,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"W. Garfield Weston Foundation","keywords":"ABCA1; Liver X receptor; Apolipoprotein E; Downregulation and upregulation; Microglia; Purinergic receptor; Cell biology; Receptor; Reverse cholesterol transport; Cholesterol; Biology; Chemistry; Nuclear receptor; Pharmacology; Biochemistry; Internal medicine; Medicine; Inflammation; Immunology; Disease; Lipoprotein; Gene; Transcription factor; Transporter","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001445853,0.0003415351,0.0003322623,0.0003776502,0.0001498003,0.0002916138,0.0001797765,0.0002717519,0.002310174],"category_scores_gemma":[0.0001165579,0.0001050933,0.0003224968,0.0001710271,0.0001964541,0.0002107598,0.0002684895,0.0004913876,0.0003658156],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001536995,"about_ca_system_score_gemma":0.0002314356,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002085311,"about_ca_topic_score_gemma":0.0007492047,"domain_scores_codex":[0.9998838,0.00003372376,0.00001315141,0.00001459176,0.00003042263,0.00002433975],"domain_scores_gemma":[0.9999348,0.00001952739,0.00001454094,0.000006632447,0.00001006685,0.0000145035],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006410399,0.0003028618,0.0002001888,0.0003204862,0.00004073942,0.0002302608,0.00003222821,0.0001883085,0.9801217,0.0007071622,0.0002750484,0.01694005],"study_design_scores_gemma":[0.0002913868,0.004355633,0.002128345,0.00002693843,0.00008093827,0.0005265862,0.0000382578,0.0006974124,0.9789526,0.0001462232,0.01274438,0.00001112211],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.95552,0.02426443,0.006959017,0.0005289319,0.0001995714,0.0003767278,0.0005226303,0.0002312739,0.01139741],"genre_scores_gemma":[0.9694456,0.01266273,0.00806433,0.0002925242,0.000115119,0.0002783881,0.000591489,0.00002245436,0.008527325],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002310174,"threshold_uncertainty_score":0.007728338,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1711315166482834,"score_gpt":0.373414181473283,"score_spread":0.2022826648249996,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}