{"id":"W2794070712","doi":"10.1194/jlr.m081851","title":"Small molecule inducers of ABCA1 and apoE that act through indirect activation of the LXR pathway","year":2018,"lang":"en","type":"article","venue":"Journal of Lipid Research","topic":"Cholesterol and Lipid Metabolism","field":"Medicine","cited_by":48,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"W. Garfield Weston Foundation","keywords":"ABCA1; Liver X receptor; Apolipoprotein E; Downregulation and upregulation; Microglia; Purinergic receptor; Cell biology; Receptor; Reverse cholesterol transport; Cholesterol; Biology; Chemistry; Nuclear receptor; Pharmacology; Biochemistry; Internal medicine; Medicine; Inflammation; Immunology; Disease; Lipoprotein; Gene; Transcription factor; Transporter","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002011437,0.00009743487,0.0003847568,0.0002615989,0.0000864149,0.00001728387,0.0002306371,0.0001165812,0.00006089927],"category_scores_gemma":[0.0007430367,0.00005561378,0.0001315352,0.0004678562,0.0004310532,0.0001635813,0.0001269139,0.0007356658,0.00000196454],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004916458,"about_ca_system_score_gemma":0.0004045577,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005715554,"about_ca_topic_score_gemma":0.000007394626,"domain_scores_codex":[0.9979244,0.0003225103,0.0004121838,0.0001227274,0.0009793852,0.0002388117],"domain_scores_gemma":[0.9981657,0.0002325546,0.0003885332,0.0002811029,0.0008191818,0.0001129282],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000994804,0.0002976445,0.03158478,0.0002180651,0.0001826838,0.000005416342,0.005652468,0.000001081326,0.9416053,0.0001062069,0.001784739,0.01756686],"study_design_scores_gemma":[0.001560655,0.0007481197,0.2026336,0.0005023303,0.00003119301,0.00007489607,0.0007556794,0.000008958566,0.7805604,0.0001262331,0.01295059,0.00004725561],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9929744,0.0002648291,0.00002462706,0.002113377,0.0003315507,0.0002131378,0.000002754323,0.000002715473,0.004072601],"genre_scores_gemma":[0.9976932,0.0002645788,0.0002574258,0.0001309703,0.001225408,0.000001628442,5.319311e-7,0.00001584891,0.0004104179],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1710489,"threshold_uncertainty_score":0.3196143,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1711315166482834,"score_gpt":0.373414181473283,"score_spread":0.2022826648249996,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}