{"id":"W2794081110","doi":"10.1093/nar/gky008","title":"The prolyl isomerase FKBP25 regulates microtubule polymerization impacting cell cycle progression and genomic stability","year":2018,"lang":"en","type":"article","venue":"Nucleic Acids Research","topic":"Signaling Pathways in Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; University of British Columbia; BC Cancer Agency; University of Victoria","funders":"BC Cancer Agency; Canada's Michael Smith Genome Sciences Centre","keywords":"Biology; Cell biology; Prolyl isomerase; Interactome; Mitosis; Chromatin; FKBP; Microtubule polymerization; Microtubule; PIN1; Biochemistry; DNA; Isomerase; Tubulin; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001248349,0.0001357994,0.00009301215,0.00004073697,0.000883201,0.0001521708,0.0003228408,0.0001375589,0.00005323319],"category_scores_gemma":[0.0004424183,0.0001016793,0.00004380703,0.0001899503,0.0008066765,0.000009471106,0.000434646,0.0001973531,0.00002614594],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004085812,"about_ca_system_score_gemma":0.0001730429,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002408499,"about_ca_topic_score_gemma":0.00000841213,"domain_scores_codex":[0.9981759,0.0003239975,0.0001988518,0.0004682169,0.000316992,0.0005160477],"domain_scores_gemma":[0.9988205,0.0000746258,0.00006629206,0.0006026113,0.0002609473,0.0001750573],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002998455,0.0000706643,0.009410876,0.00002950355,0.00001250662,0.000001297794,0.0002224473,9.424615e-7,0.9761524,0.000007985464,0.0003780369,0.01341348],"study_design_scores_gemma":[0.0003747278,0.0004331965,0.00530242,0.0000216526,0.000005379204,0.000004721391,0.000277308,0.0003946062,0.9903249,0.0001540612,0.002582734,0.0001243374],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9961229,0.002134374,0.00004828915,0.000289503,0.00006825102,0.0005115576,0.0000179935,0.00002369386,0.0007834625],"genre_scores_gemma":[0.9987815,0.0001194738,0.0003567663,0.00003736218,0.0003495221,0.00004720287,0.00002834009,0.00003788425,0.000241964],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01417244,"threshold_uncertainty_score":0.6792958,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02302847233708094,"score_gpt":0.3301560289590636,"score_spread":0.3071275566219827,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}