{"id":"W2794150437","doi":"10.1089/aid.2017.0184","title":"Short Communication: Dolutegravir-Based Regimens Are Active in Integrase Strand Transfer Inhibitor–Naive Patients with Nucleoside Reverse Transcriptase Inhibitor Resistance","year":2018,"lang":"en","type":"article","venue":"AIDS Research and Human Retroviruses","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"GlaxoSmithKline (Canada)","funders":"ViiV Healthcare","keywords":"Dolutegravir; Raltegravir; Integrase inhibitor; Medicine; Virology; Lamivudine; Darunavir; Reverse-transcriptase inhibitor; Drug resistance; Nucleoside Reverse Transcriptase Inhibitor; Emtricitabine; Internal medicine; Pharmacology; Gastroenterology; Viral load; Human immunodeficiency virus (HIV); Virus; Antiretroviral therapy; Biology; Microbiology; Hepatitis B virus","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0005522451,0.0003363157,0.000502757,0.0007655222,0.0005924081,0.00009374446,0.0001992807,0.0001541182,0.0001308074],"category_scores_gemma":[0.00008632529,0.0002571091,0.000076747,0.0007957665,0.001328196,0.0003185188,0.00003914958,0.0007727405,0.00002650277],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003626496,"about_ca_system_score_gemma":0.0002400394,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002167682,"about_ca_topic_score_gemma":0.00491794,"domain_scores_codex":[0.9970728,0.0003049669,0.000420717,0.0006134184,0.0009196647,0.0006684165],"domain_scores_gemma":[0.998044,0.0001837142,0.00004318342,0.000648025,0.0006783362,0.0004026978],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0107137,0.00226652,0.9630131,0.0002255017,0.0003058414,0.0002473854,0.004131318,9.547582e-8,0.001505236,0.001210558,0.01484906,0.001531675],"study_design_scores_gemma":[0.02018499,0.006492618,0.8949688,0.003595931,0.0002248737,0.000004607404,0.005143901,0.000001495481,0.03631837,0.0004951733,0.03182175,0.0007474794],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9953029,0.0002582111,0.00001717994,0.00103632,0.00002536624,0.001254009,0.0001704669,0.00005277794,0.001882813],"genre_scores_gemma":[0.9948587,0.0001019653,0.0008577263,0.0001915358,0.00008532593,0.0001373227,0.0002611109,0.00005205349,0.003454301],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0680443,"threshold_uncertainty_score":0.9999881,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04577232815104935,"score_gpt":0.3268700893455081,"score_spread":0.2810977611944587,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}