{"id":"W2794207831","doi":"10.1093/nar/gky024","title":"Structural properties and gene-silencing activity of chemically modified DNA–RNA hybrids with parallel orientation","year":2018,"lang":"en","type":"article","venue":"Nucleic Acids Research","topic":"DNA and Nucleic Acid Chemistry","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Ministerio de Economía y Competitividad; Gebert Rüf Stiftung; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung","keywords":"Biology; DNA; Genetics; Gene; RNA; Hybrid; Gene silencing; RNA-induced silencing complex; Orientation (vector space); Computational biology; Cell biology; RNA interference; Botany","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001365898,0.0002561085,0.000125317,0.0001300814,0.0001031992,0.0002335372,0.0001816161,0.0002720176,0.0005165462],"category_scores_gemma":[0.0002299691,0.0001534175,0.000151511,0.00009571245,0.0001879319,0.0001781807,0.0001056388,0.0003031884,0.0001522019],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002257024,"about_ca_system_score_gemma":0.00009767152,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002614769,"about_ca_topic_score_gemma":0.0004172605,"domain_scores_codex":[0.9998963,0.00001610456,0.000006366715,0.00002769656,0.00004086725,0.00001268355],"domain_scores_gemma":[0.9998287,0.00004720361,0.00006387842,0.00001507303,0.00002111374,0.0000239683],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001553501,0.000006614663,0.00005755165,0.00001026209,0.000003552269,0.00001993746,0.000009121142,0.0001119571,0.999289,0.00006211486,0.000005465396,0.0004088505],"study_design_scores_gemma":[0.000002752048,0.0000851365,0.0004055392,5.94229e-7,0.000005506777,0.00004841258,0.000004993491,0.0003611932,0.998767,0.0000128992,0.0003027888,0.000003214955],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9949954,0.0004787103,0.003484683,0.00003171152,0.00001222322,0.00001547672,0.00006567291,0.00004158756,0.0008746089],"genre_scores_gemma":[0.995886,0.000156298,0.002840989,0.00002687327,0.000005935699,0.00002093996,0.0001526871,0.0000157024,0.00089444],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005165462,"threshold_uncertainty_score":0.001727998,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04128652335630655,"score_gpt":0.2981384121018509,"score_spread":0.2568518887455444,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}