{"id":"W2794232784","doi":"10.1093/jcag/gwy008.103","title":"A102 THIOPURINE METABOLITE LEVEL MONITORING LEADS TO INDIVIDUALIZED AND OPTIMIZED THIOPURINE THERAPY IN ADULT INFLAMMATORY BOWEL DISEASE (IBD)","year":2018,"lang":"en","type":"article","venue":"Journal of the Canadian Association of Gastroenterology","topic":"Acute Lymphoblastic Leukemia research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Thiopurine methyltransferase; Medicine; Allopurinol; Metabolite; Therapeutic drug monitoring; Internal medicine; Gastroenterology; Azathioprine; Dosing; Inflammatory bowel disease; Xanthine oxidase; Mercaptopurine; Toxicity; Pharmacology; Pharmacokinetics; Disease; Chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005839866,0.0001546973,0.0002715533,0.0003275699,0.0001086332,0.000500792,0.0001004234,0.0001567635,0.0007359034],"category_scores_gemma":[0.001253311,0.0000625703,0.0001504139,0.0004307971,0.00008935999,0.0002799493,0.0001875473,0.0002470729,0.0002213546],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002171623,"about_ca_system_score_gemma":0.0001683881,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004547804,"about_ca_topic_score_gemma":0.000901704,"domain_scores_codex":[0.9997132,0.00009391757,0.00006123433,0.00003832765,0.00007751071,0.00001576371],"domain_scores_gemma":[0.9994361,0.000119513,0.0002727717,0.00003059979,0.00008969383,0.00005139736],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001344579,0.0002544636,0.674055,0.0002241215,0.00008726528,0.0005722525,0.0001913518,0.001001432,0.01460489,0.0002541966,0.002023638,0.3053869],"study_design_scores_gemma":[0.00006100126,0.001603688,0.9748961,0.0001591274,0.0001292642,0.002368323,0.0001873281,0.002961747,0.008778433,0.0003416954,0.008500429,0.00001278091],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9772342,0.01093187,0.005327621,0.0008123663,0.00004541267,0.00007630866,0.0004782884,0.0001548382,0.004939057],"genre_scores_gemma":[0.9936553,0.001982013,0.003595413,0.0001382537,0.0000339567,0.00001630409,0.0002270667,0.000007058838,0.0003445782],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007359034,"threshold_uncertainty_score":0.003088474,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0162873083779811,"score_gpt":0.2749635307412416,"score_spread":0.2586762223632605,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}