{"id":"W2794289687","doi":"10.1021/acsomega.7b01654","title":"Structural Switch from Hairpin to Duplex/Antiparallel G-Quadruplex at Single-Nucleotide Polymorphism (SNP) Site of Human Apolipoprotein E (<i>APOE</i>) Gene Coding Region","year":2018,"lang":"en","type":"article","venue":"ACS Omega","topic":"DNA and Nucleic Acid Chemistry","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"Innovation Cluster (Canada)","funders":"University of Delhi; Council of Scientific and Industrial Research, India","keywords":"Antiparallel (mathematics); Single-nucleotide polymorphism; Apolipoprotein E; Genetics; Gene; Coding region; Duplex (building); SNP; Biology; G-quadruplex; DNA; Genotype; Medicine; Physics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001211252,0.0001877629,0.0001734975,0.0002523347,0.0002116657,0.0001726937,0.0002516549,0.0002952362,0.009488527],"category_scores_gemma":[0.0002449233,0.0001506889,0.0001682499,0.0001386187,0.0001607309,0.0002278597,0.0001054859,0.0003677653,0.001482907],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001486055,"about_ca_system_score_gemma":0.000112676,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003042992,"about_ca_topic_score_gemma":0.0004943626,"domain_scores_codex":[0.9999141,0.00001033716,0.000005385102,0.00004004871,0.00001933724,0.00001084775],"domain_scores_gemma":[0.9998835,0.00003613313,0.00002857325,0.00001090542,0.00001880561,0.00002192888],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001643834,0.00003353969,0.0005463792,0.00007397563,0.000007670107,0.0002020547,0.0000532548,0.00007047677,0.9926658,0.0002954789,0.001069745,0.004817284],"study_design_scores_gemma":[0.00007341064,0.0007619493,0.01648591,0.0000332558,0.00003578376,0.001368281,0.0001311622,0.004025729,0.957123,0.0006230259,0.01930592,0.00003257378],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.956699,0.00100491,0.02505962,0.0004622454,0.0003114241,0.0001579369,0.002948037,0.001831681,0.0115252],"genre_scores_gemma":[0.9597855,0.0005274824,0.02563996,0.0003818241,0.00002987163,0.0001810187,0.002351518,0.0001428429,0.01095996],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009488527,"threshold_uncertainty_score":0.03174227,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02354493213040967,"score_gpt":0.2554920743406898,"score_spread":0.2319471422102801,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}