{"id":"W2794289687","doi":"10.1021/acsomega.7b01654","title":"Structural Switch from Hairpin to Duplex/Antiparallel G-Quadruplex at Single-Nucleotide Polymorphism (SNP) Site of Human Apolipoprotein E (<i>APOE</i>) Gene Coding Region","year":2018,"lang":"en","type":"article","venue":"ACS Omega","topic":"DNA and Nucleic Acid Chemistry","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"Innovation Cluster (Canada)","funders":"University of Delhi; Council of Scientific and Industrial Research, India","keywords":"Antiparallel (mathematics); Single-nucleotide polymorphism; Apolipoprotein E; Genetics; Gene; Coding region; Duplex (building); SNP; Biology; G-quadruplex; DNA; Genotype; Medicine; Physics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.00009171831,0.0003619486,0.0003749072,0.00006690028,0.0002740456,0.00003985328,0.0004868234,0.0003010753,0.00005200886],"category_scores_gemma":[0.00006246949,0.0003683695,0.000161073,0.0001621972,0.0002789497,0.00001402928,0.0005481002,0.0001285221,0.0000607504],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006042133,"about_ca_system_score_gemma":0.00003498515,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006273836,"about_ca_topic_score_gemma":0.0002352278,"domain_scores_codex":[0.9979524,0.00003978983,0.0004757724,0.000724802,0.0002758881,0.0005313372],"domain_scores_gemma":[0.9983933,0.00001348304,0.0002652534,0.0009422154,0.0001465847,0.0002391764],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00020921,0.00004136589,0.006889292,0.00002090397,0.00008152857,0.00001267349,0.0001860397,0.000006760456,0.9862899,0.0000199767,0.005720933,0.000521444],"study_design_scores_gemma":[0.0009068924,0.0003913509,0.006594957,0.00004721362,0.0000379109,0.00003159457,0.00004947397,0.00003487983,0.9863799,0.00007927963,0.005000462,0.0004460781],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979579,0.0002923738,0.0001710738,0.0002875164,0.0002533742,0.0002402869,0.00009184294,0.0000452528,0.0006603271],"genre_scores_gemma":[0.994574,0.00002349106,0.001212471,0.0005552238,0.001354382,0.00001372424,0.0004246705,0.00007397268,0.001768064],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003383952,"threshold_uncertainty_score":0.9998768,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02354493213040967,"score_gpt":0.2554920743406898,"score_spread":0.2319471422102801,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}