{"id":"W2794290913","doi":"10.3390/ijms19020545","title":"Alternative Splicing as a Target for Cancer Treatment","year":2018,"lang":"en","type":"review","venue":"International Journal of Molecular Sciences","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":114,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke","funders":"","keywords":"RNA splicing; Alternative splicing; Exon; Biology; Intron; Minigene; Gene; Computational biology; Exonic splicing enhancer; Genetics; RNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005375542,0.0002262888,0.0004754115,0.0002644192,0.00008504644,0.0001282636,0.001093475,0.0001105096,0.00002670594],"category_scores_gemma":[0.0002158045,0.0001534695,0.0006239586,0.0001081437,0.0001935212,0.00001161305,0.0001137127,0.00009336179,0.000006410941],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001373771,"about_ca_system_score_gemma":0.001218604,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008702019,"about_ca_topic_score_gemma":0.00001426317,"domain_scores_codex":[0.9982791,0.00009087,0.0004734565,0.0003190371,0.0005883744,0.0002491483],"domain_scores_gemma":[0.9984497,0.00004826981,0.0006398455,0.0001259526,0.000620066,0.0001161486],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001077222,0.0001186555,0.00001453434,0.0002346071,0.001963403,0.0001422915,0.00005233968,0.0002171917,0.00851155,0.0004454078,0.0007922607,0.9874001],"study_design_scores_gemma":[0.0003657926,0.001835556,3.287531e-7,0.001586453,0.0001071064,0.0002606401,0.00002104609,0.00006769251,0.01160978,0.0003472086,0.9836208,0.0001776247],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.005050126,0.9885223,0.004686585,0.0001236723,0.000947034,0.0002853779,0.00005887262,0.000001969595,0.0003240438],"genre_scores_gemma":[0.0005933538,0.9945006,0.002684239,0.0001009635,0.001393666,0.00004740107,0.00002351644,0.00002202177,0.0006342804],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9872224,"threshold_uncertainty_score":0.6258305,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05538827567036293,"score_gpt":0.4337726614466313,"score_spread":0.3783843857762684,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}