{"id":"W2794290913","doi":"10.3390/ijms19020545","title":"Alternative Splicing as a Target for Cancer Treatment","year":2018,"lang":"en","type":"review","venue":"International Journal of Molecular Sciences","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":114,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke","funders":"","keywords":"RNA splicing; Alternative splicing; Exon; Biology; Intron; Minigene; Gene; Computational biology; Exonic splicing enhancer; Genetics; RNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000405096,0.000415633,0.00076294,0.001295767,0.0002542243,0.0006824736,0.0006800807,0.0009219056,0.004786135],"category_scores_gemma":[0.000485851,0.0001593793,0.0004327531,0.0007723041,0.0004116026,0.0007700612,0.0004696095,0.002033624,0.002018527],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004726827,"about_ca_system_score_gemma":0.0005188227,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003819223,"about_ca_topic_score_gemma":0.000965736,"domain_scores_codex":[0.9998247,0.00003229531,0.00001769122,0.00003527603,0.00007102364,0.0000191025],"domain_scores_gemma":[0.9998193,0.000082885,0.00002201974,0.000008528576,0.00004817531,0.00001906095],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00009628679,0.0001357488,0.0002809259,0.007751776,0.0000795713,0.0003721055,0.00005305123,0.0003766469,0.00603998,0.007747578,0.03155658,0.9455097],"study_design_scores_gemma":[0.00001593094,0.000121513,0.0005956821,0.001244549,0.00006968847,0.00154203,0.00003326352,0.0001316768,0.002258664,0.002782241,0.9911902,0.00001455778],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0003365724,0.9960984,0.0004007475,0.0006853955,0.0003774071,0.000008517508,0.0000279787,0.00001662743,0.002048314],"genre_scores_gemma":[0.00332202,0.9932792,0.0005179785,0.0005502586,0.0003175378,0.00001560008,0.00008135346,0.000004995075,0.001911137],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.004786135,"threshold_uncertainty_score":0.01601124,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05538827567036293,"score_gpt":0.4337726614466313,"score_spread":0.3783843857762684,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}