{"id":"W2794318060","doi":"10.3389/fphar.2018.00121","title":"Peripheral Etanercept Administration Normalizes Behavior, Hippocampal Neurogenesis, and Hippocampal Reelin and GABAA Receptor Expression in a Preclinical Model of Depression","year":2018,"lang":"en","type":"article","venue":"Frontiers in Pharmacology","topic":"Stress Responses and Cortisol","field":"Neuroscience","cited_by":51,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Victoria; University of Saskatchewan","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Dentate gyrus; Subgranular zone; Neurogenesis; Hippocampal formation; Neuroscience; Reelin; Behavioural despair test; Hippocampus; Etanercept; Psychology; GABAergic; Serotonin reuptake inhibitor; Medicine; Endocrinology; Internal medicine; Antidepressant; Inhibitory postsynaptic potential; Receptor; Biology; Neural stem cell; Tumor necrosis factor alpha; Subventricular zone","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001298427,0.0002029669,0.0003543762,0.0001996124,0.00008691594,0.00002017613,0.0002009389,0.0002148333,0.0001178442],"category_scores_gemma":[0.0001702711,0.0001944446,0.00004294372,0.0001837472,0.0005186043,0.0002092315,0.0001590195,0.0002698754,0.000001147887],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003642672,"about_ca_system_score_gemma":0.00009682421,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001285598,"about_ca_topic_score_gemma":0.00002497953,"domain_scores_codex":[0.9977273,0.0005539676,0.0005476547,0.0006272435,0.0001952465,0.0003486092],"domain_scores_gemma":[0.9993333,0.0001532831,0.0001798419,0.0001633961,0.00003207631,0.0001381666],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004122015,0.0002516437,0.1768724,0.00002232348,0.00000248704,0.00003014464,0.000503442,0.00005430468,0.7879754,0.000005117326,0.0009091827,0.02925153],"study_design_scores_gemma":[0.004039697,0.001158618,0.07798932,0.0000673637,0.00004955574,0.00006156964,0.0002483088,0.09214202,0.8232451,0.0001924049,0.000446329,0.0003596859],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966699,0.0006269313,0.001092878,0.00009504014,0.000936188,0.0004611002,0.00003184795,0.00002457841,0.00006154461],"genre_scores_gemma":[0.9934425,0.002156571,0.003797392,0.0002893333,0.00009876663,0.00012439,0.000003904286,0.00002113532,0.00006601145],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0988831,"threshold_uncertainty_score":0.7929222,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04281211566400737,"score_gpt":0.3453174338130715,"score_spread":0.3025053181490641,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}