{"id":"W2794321264","doi":"10.1111/adb.12602","title":"Preclinical evidence for combining the 5‐<scp>HT<sub>2C</sub></scp> receptor agonist lorcaserin and varenicline as a treatment for nicotine dependence","year":2018,"lang":"en","type":"article","venue":"Addiction Biology","topic":"Neurotransmitter Receptor Influence on Behavior","field":"Neuroscience","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Centre for Addiction and Mental Health","funders":"Canadian Institutes of Health Research","keywords":"Varenicline; Nicotine; Pharmacology; Agonist; Cytisine; Smoking cessation; Partial agonist; Nicotinic acetylcholine receptor; Nicotinic agonist; Medicine; Receptor; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0005356304,0.0003409463,0.0003668514,0.00009026482,0.000673295,0.0000938132,0.0004486614,0.000239418,0.00008421336],"category_scores_gemma":[0.003248239,0.0002516081,0.0001855523,0.0002360761,0.0009957473,0.0002656408,0.0001010929,0.000223669,0.0001630117],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008213082,"about_ca_system_score_gemma":0.0001185084,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000409287,"about_ca_topic_score_gemma":0.00006839621,"domain_scores_codex":[0.9971294,0.000357797,0.0006269828,0.001115877,0.0001581028,0.0006118202],"domain_scores_gemma":[0.9932902,0.005526983,0.000315594,0.0005182244,0.000164466,0.0001844738],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003075578,0.0001785622,0.002801483,0.00001094558,0.00001825222,0.000001416239,0.0002343223,0.000002158796,0.9628742,0.0005844188,0.001189239,0.03179738],"study_design_scores_gemma":[0.001851589,0.006367532,0.001262231,0.00006351309,0.0001056968,0.0001097614,0.00004149325,0.0003784915,0.9288729,0.0004677788,0.06035095,0.0001280527],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9920191,0.0002078267,0.002289581,0.001223926,0.001566264,0.002175313,0.0002690732,0.0001913818,0.00005753719],"genre_scores_gemma":[0.9941621,0.0007285968,0.0007282211,0.001974308,0.0005247404,0.001526609,0.00003050495,0.00004891917,0.0002759929],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05916171,"threshold_uncertainty_score":0.9999936,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1282529448562862,"score_gpt":0.3878410868534924,"score_spread":0.2595881419972063,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}