{"id":"W2794321264","doi":"10.1111/adb.12602","title":"Preclinical evidence for combining the 5‐<scp>HT<sub>2C</sub></scp> receptor agonist lorcaserin and varenicline as a treatment for nicotine dependence","year":2018,"lang":"en","type":"article","venue":"Addiction Biology","topic":"Neurotransmitter Receptor Influence on Behavior","field":"Neuroscience","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Centre for Addiction and Mental Health","funders":"Canadian Institutes of Health Research","keywords":"Varenicline; Nicotine; Pharmacology; Agonist; Cytisine; Smoking cessation; Partial agonist; Nicotinic acetylcholine receptor; Nicotinic agonist; Medicine; Receptor; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002942255,0.0005313808,0.000480556,0.0003351181,0.000179546,0.0003154032,0.0006416533,0.0005225096,0.003180985],"category_scores_gemma":[0.000270465,0.0001915684,0.000424027,0.0001788807,0.0003673939,0.0003781691,0.0001791043,0.001181762,0.0005554344],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003226173,"about_ca_system_score_gemma":0.0003913956,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008219108,"about_ca_topic_score_gemma":0.002778056,"domain_scores_codex":[0.9998686,0.00003812339,0.00001232122,0.00001873131,0.00003479271,0.00002738004],"domain_scores_gemma":[0.9996815,0.00005322144,0.0001018061,0.0000339121,0.00003822277,0.0000913923],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00558047,0.005043117,0.001068199,0.000456901,0.0001857916,0.00025616,0.00004726613,0.0003729126,0.9486303,0.0004664868,0.0006959935,0.03719645],"study_design_scores_gemma":[0.004351149,0.2191147,0.03689422,0.0002219459,0.0008274158,0.002687885,0.0001136495,0.001945575,0.7127121,0.0005731334,0.0205,0.00005822036],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.98506,0.00496908,0.00199014,0.000792674,0.00008717115,0.0002985795,0.0007512979,0.0001735473,0.005877575],"genre_scores_gemma":[0.9855482,0.007485951,0.002689235,0.0002719162,0.0001070553,0.0001550568,0.00128882,0.0000205953,0.002433093],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003180985,"threshold_uncertainty_score":0.01064146,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1282529448562862,"score_gpt":0.3878410868534924,"score_spread":0.2595881419972063,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}