{"id":"W2794369551","doi":"10.1038/s41598-018-21201-7","title":"Development of a primary human Small Intestine-on-a-Chip using biopsy-derived organoids","year":2018,"lang":"en","type":"article","venue":"Scientific Reports","topic":"3D Printing in Biomedical Research","field":"Engineering","cited_by":732,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Intellectual and Developmental Disabilities Research Center; U.S. Food and Drug Administration; National Institutes of Health; Defense Advanced Research Projects Agency; Ragon Institute of MGH, MIT and Harvard; North American Society for Pediatric Gastroenterology, Hepatology and Nutrition; Eunice Kennedy Shriver National Institute of Child Health and Human Development; Hansjörg Wyss Institute for Biologically Inspired Engineering, Harvard University; Harvard University; Harvard Digestive Diseases Center, Harvard University; Hamilton Health Sciences Foundation; National Institute of Diabetes and Digestive and Kidney Diseases; Bill and Melinda Gates Foundation","keywords":"Organoid; Small intestine; Lumen (anatomy); Cell biology; Intestinal epithelium; Biology; Crypt; Intestinal mucosa; Epithelium; Chemistry; Biochemistry; Internal medicine; Medicine; Endocrinology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005457145,0.0004943266,0.0004892001,0.0003693922,0.0002787322,0.0005763164,0.0007621069,0.0007533485,0.001517317],"category_scores_gemma":[0.000441194,0.0004707438,0.000756599,0.0001858623,0.0002877185,0.000343499,0.0006036075,0.0008994211,0.001334534],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002691505,"about_ca_system_score_gemma":0.0004776011,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008682834,"about_ca_topic_score_gemma":0.0020478,"domain_scores_codex":[0.9996765,0.00003163002,0.00002891577,0.0001023421,0.0001149992,0.00004559112],"domain_scores_gemma":[0.9995779,0.0001148003,0.00004756435,0.0001005897,0.00008177524,0.00007740996],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004168601,0.00002906976,0.0003784994,0.0001407299,0.00001656192,0.0001961948,0.00004036788,0.0005170848,0.9930598,0.0001789691,0.0003805623,0.005020503],"study_design_scores_gemma":[0.00002160465,0.0002799674,0.003409768,0.00003053451,0.00005081886,0.0008100029,0.00007081513,0.004147426,0.9746105,0.00008962055,0.01645013,0.00002893733],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.3412278,0.004412489,0.6328347,0.0005945665,0.0008944285,0.002021957,0.003999579,0.003168035,0.01084636],"genre_scores_gemma":[0.4911999,0.002174497,0.4940628,0.000592377,0.00005480178,0.001663362,0.003329796,0.0002680913,0.006654291],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.001517317,"threshold_uncertainty_score":0.005075932,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06235260887607497,"score_gpt":0.2957405837469911,"score_spread":0.2333879748709162,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}