{"id":"W2794413974","doi":"10.1186/s13104-018-3243-7","title":"Fanconi anemia core complex-dependent HES1 mono-ubiquitination regulates its transcriptional activity","year":2018,"lang":"en","type":"article","venue":"BMC Research Notes","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Wilfrid Laurier University; University Health Network","funders":"Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research; Fondation CHU de Québec; Université Laval","keywords":"Ubiquitin; HES1; Transcriptional activity; Medicine; Fanconi anemia; Bioinformatics; Genetics; Computational biology; Cancer research; Biology; Cell biology; Transcription factor; Gene; Downregulation and upregulation; DNA repair","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001087152,0.0002118543,0.000108579,0.0001116157,0.0001286601,0.0002306534,0.0001235819,0.0001081738,0.001769787],"category_scores_gemma":[0.0001043552,0.00007849281,0.0001413479,0.00008920546,0.0001635548,0.0001451287,0.0002041938,0.0001884045,0.0004582661],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003223711,"about_ca_system_score_gemma":0.0001202374,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003067743,"about_ca_topic_score_gemma":0.0006826093,"domain_scores_codex":[0.999904,0.00001021242,0.000007047346,0.00002991007,0.00002453681,0.00002425617],"domain_scores_gemma":[0.9999185,0.00001218977,0.0000316959,0.000008061382,0.00001480965,0.00001482366],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001445067,0.00001510332,0.001042002,0.00002814209,0.000005806806,0.00004544011,0.00001602286,0.00009774842,0.9965572,0.0001316271,0.00009504427,0.001821422],"study_design_scores_gemma":[0.00001047577,0.00006644991,0.02497038,0.000007031811,0.00001025093,0.0001939144,0.00002600965,0.001404426,0.9712136,0.00008096757,0.002012515,0.000004023694],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9951935,0.001492148,0.001406332,0.00006033776,0.00001507442,0.000007317281,0.0002394568,0.00004452461,0.001541171],"genre_scores_gemma":[0.9972466,0.0002859436,0.0004715187,0.00001956319,0.000003442008,0.000005862495,0.0002618047,0.000008162059,0.001696994],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001769787,"threshold_uncertainty_score":0.005920529,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2031850061811848,"score_gpt":0.4067342501965093,"score_spread":0.2035492440153245,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}