{"id":"W2794420720","doi":"10.1016/j.ahj.2018.03.001","title":"An open-Label, 2 × 2 factorial, randomized controlled trial to evaluate the safety of apixaban vs. vitamin K antagonist and aspirin vs. placebo in patients with atrial fibrillation and acute coronary syndrome and/or percutaneous coronary intervention: Rationale and design of the AUGUSTUS trial","year":2018,"lang":"en","type":"article","venue":"American Heart Journal","topic":"Atrial Fibrillation Management and Outcomes","field":"Medicine","cited_by":87,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta; St. Michael's Hospital; Canadian VIGOUR Centre","funders":"Pfizer; Bristol-Myers Squibb","keywords":"Medicine; Apixaban; Acute coronary syndrome; Vitamin K antagonist; Percutaneous coronary intervention; Aspirin; Internal medicine; Atrial fibrillation; Myocardial infarction; Randomized controlled trial; Cardiology; Conventional PCI; Antithrombotic; Stroke (engine); Coronary artery disease; Warfarin; Rivaroxaban","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.007087893,0.00340296,0.005892312,0.0005735882,0.0009095178,0.00153529,0.001399293,0.003363421,0.008328616],"category_scores_gemma":[0.007294538,0.001040639,0.002585744,0.0005419201,0.002011554,0.002273313,0.000980905,0.003123402,0.001366304],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008110146,"about_ca_system_score_gemma":0.001571601,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004512442,"about_ca_topic_score_gemma":0.0009078784,"domain_scores_codex":[0.9949564,0.003691175,0.0002446692,0.0005496835,0.0002441779,0.0003138136],"domain_scores_gemma":[0.9971117,0.001095127,0.0006644485,0.0002463198,0.0002576505,0.0006246989],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9904507,0.003718414,0.0002869076,0.0004971458,0.0008653189,0.00002414307,0.00003293892,0.0002288819,0.0005240259,0.0002459312,0.0004160119,0.002709632],"study_design_scores_gemma":[0.9777404,0.02040272,0.0003841576,0.00002409355,0.000362292,0.00001074665,0.000009041519,0.0004617952,0.0000549387,0.0002499866,0.0002914451,0.000008389948],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"protocol","genre_scores_codex":[0.9016599,0.007751341,0.005347331,0.004158285,0.003672059,0.06900288,0.00288931,0.0003842093,0.005134774],"genre_scores_gemma":[0.8470475,0.002840536,0.01359495,0.00511092,0.003113349,0.120265,0.002012486,0.00004997684,0.005965301],"genre_candidate":"protocol","genre_consensus":null,"teacher_disagreement_score":0.008328616,"threshold_uncertainty_score":0.03748477,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03782941610953171,"score_gpt":0.3404419259891938,"score_spread":0.3026125098796621,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}