{"id":"W2794622061","doi":"10.3390/ijms19041010","title":"Human Mitochondrial HMG-CoA Synthase Deficiency: Role of Enzyme Dimerization Surface and Characterization of Three New Patients","year":2018,"lang":"en","type":"article","venue":"International Journal of Molecular Sciences","topic":"Biochemical and Molecular Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre hospitalier universitaire de Québec; Centre Hospitalier de l’Université de Montréal","funders":"Ministerio de Asuntos Económicos y Transformación Digital, Gobierno de España; Universidad de Zaragoza","keywords":"Enzyme; ATP synthase; HMG-CoA reductase; Biochemistry; Chemistry; Biology; Reductase","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002321824,0.00123008,0.0006525929,0.000977322,0.0009285971,0.0007411187,0.000488718,0.001145291,0.001421168],"category_scores_gemma":[0.001248999,0.0004434181,0.0008617394,0.000501838,0.0006993362,0.0004351039,0.000631783,0.000813186,0.000374943],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005910585,"about_ca_system_score_gemma":0.000220574,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009027386,"about_ca_topic_score_gemma":0.0005244906,"domain_scores_codex":[0.9996439,0.00003558904,0.00005540451,0.0001289671,0.00007771688,0.00005840738],"domain_scores_gemma":[0.9994233,0.0001078592,0.00009890793,0.00004870265,0.00005735232,0.0002639885],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"case_report","study_design_gemma":"case_report","study_design_scores_codex":[0.002560268,0.001292407,0.2969671,0.0002290434,0.0002487162,0.4414847,0.008239217,0.001356972,0.2004173,0.001776109,0.001783293,0.04364482],"study_design_scores_gemma":[0.0002137968,0.001629109,0.2243915,0.00002690837,0.0001662073,0.7345162,0.0008560354,0.002292129,0.02855923,0.0006082059,0.006621586,0.0001190633],"study_design_candidate":"case_report","study_design_consensus":"case_report","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980762,0.0002270882,0.0008634552,0.0001549902,0.0000216176,0.00002552409,0.0001047186,0.00002300881,0.0005034192],"genre_scores_gemma":[0.9983624,0.0001744404,0.0005531014,0.0000980507,0.0000340539,0.00001910517,0.0001703079,0.00001331772,0.000575293],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001421168,"threshold_uncertainty_score":0.004754245,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01190668030043904,"score_gpt":0.2820227305018927,"score_spread":0.2701160502014537,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}