{"id":"W2794713784","doi":"10.3390/cancers10040101","title":"Epigenetic Modifications as Biomarkers of Tumor Development, Therapy Response, and Recurrence across the Cancer Care Continuum","year":2018,"lang":"en","type":"review","venue":"Cancers","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":76,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University","funders":"Nova Scotia Health Research Foundation; Canadian Institutes of Health Research; Killam Trusts; Cancer Research Society","keywords":"Epigenetics; DNA methylation; Biomarker; Medicine; Carcinogenesis; Histone; Cancer; Colorectal cancer; Liquid biopsy; Cancer biomarkers; Disease; Bioinformatics; Cancer epigenetics; Biomarker discovery; Biology; Cancer research; Pathology; Internal medicine; Proteomics; DNA; Genetics; Histone methyltransferase; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001180578,0.0009206416,0.001304999,0.002489901,0.0003178829,0.001069002,0.001046497,0.001566329,0.002133637],"category_scores_gemma":[0.001679337,0.0002881635,0.0004424122,0.0018099,0.0008318131,0.00154363,0.0008221917,0.00222951,0.00133912],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001123826,"about_ca_system_score_gemma":0.001238521,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001462347,"about_ca_topic_score_gemma":0.002608965,"domain_scores_codex":[0.999656,0.00008052646,0.00005250542,0.00007385608,0.0001118328,0.00002528234],"domain_scores_gemma":[0.9991295,0.0004864146,0.00009490595,0.00002514388,0.000205455,0.00005861424],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00005277992,0.00004254743,0.0004418083,0.009488358,0.00009259711,0.0001695576,0.00008566389,0.0004031544,0.001044484,0.00705647,0.02646903,0.9546535],"study_design_scores_gemma":[0.000007230755,0.0000641446,0.001070353,0.003041098,0.00008036433,0.0009961039,0.00007154715,0.0001099177,0.0004571166,0.003303708,0.9907758,0.00002267163],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00007619992,0.9980707,0.0001811771,0.0006547879,0.0002981698,0.000003628918,0.00001751043,0.000007557474,0.0006902411],"genre_scores_gemma":[0.0007152054,0.9979718,0.0002378446,0.0003011344,0.0002336639,0.000007529246,0.00002377306,0.000001959758,0.0005070583],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002489901,"threshold_uncertainty_score":0.008153975,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05186722220076322,"score_gpt":0.3816816901792969,"score_spread":0.3298144679785337,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}