{"id":"W2794717908","doi":"10.1038/s41598-018-23682-y","title":"Hidden genomic MHC disparity between HLA-matched sibling pairs in hematopoietic stem cell transplantation","year":2018,"lang":"en","type":"article","venue":"Scientific Reports","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University and Génome Québec Innovation Centre","funders":"China Scholarship Council; Tekes; Academy of Finland","keywords":"Human leukocyte antigen; Genetics; Biology; Major histocompatibility complex; Allele; MHC class I; HLA-C; Hematopoietic stem cell transplantation; Single-nucleotide polymorphism; Transplantation; Gene; Immunology; Genotype; Medicine; Antigen; Stem cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006265608,0.000110315,0.0001924164,0.0003628773,0.0002963126,0.0002434932,0.0001958729,0.0001762939,0.001635856],"category_scores_gemma":[0.002137944,0.00009860905,0.0001065986,0.0003402807,0.0003429076,0.0002310678,0.0003898037,0.0001703015,0.0001779456],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001198945,"about_ca_system_score_gemma":0.0001681989,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003488616,"about_ca_topic_score_gemma":0.000515646,"domain_scores_codex":[0.9994445,0.0002317848,0.00005163475,0.000101479,0.0001143973,0.0000562054],"domain_scores_gemma":[0.9994177,0.000180613,0.0001915286,0.00008147802,0.00003749568,0.00009112444],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001161672,0.0001481256,0.9089699,0.00007842373,0.0001168887,0.004716031,0.0009574214,0.0003188722,0.05463916,0.0009476887,0.0002744314,0.02767125],"study_design_scores_gemma":[0.00002996589,0.0007264454,0.9589689,0.00002686606,0.0001170297,0.02472872,0.001170592,0.001371877,0.009368467,0.002006813,0.001464661,0.00001969592],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9993485,0.0001942897,0.0002216751,0.00001081889,0.000004148013,0.000005067473,0.00002023173,0.000001650218,0.000193609],"genre_scores_gemma":[0.999755,0.00004362301,0.000124146,0.000007209652,0.000003550467,0.000001654975,0.00002669486,8.589009e-7,0.0000371282],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001635856,"threshold_uncertainty_score":0.005472481,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01767669564354893,"score_gpt":0.2334921683552436,"score_spread":0.2158154727116946,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}