{"id":"W2794723335","doi":"10.1158/2159-8290.cd-17-1004","title":"Response to ERBB3-Directed Targeted Therapy in <i>NRG1</i> -Rearranged Cancers","year":2018,"lang":"en","type":"article","venue":"Cancer Discovery","topic":"Lung Cancer Treatments and Mutations","field":"Medicine","cited_by":204,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Cancer Institute; National Institutes of Health; GlaxoSmithKline","keywords":"Afatinib; ERBB3; Medicine; Cancer research; ErbB; Oncology; Cancer; Internal medicine; Erlotinib; Epidermal growth factor receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001406216,0.0001944499,0.0002979101,0.0001951981,0.00008732561,0.00003976133,0.00009166095,0.00007170542,0.000421873],"category_scores_gemma":[0.00006142972,0.0001576673,0.00007772993,0.0007180217,0.00009611307,0.0002066753,0.00002093395,0.0001151008,0.00005948864],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001284256,"about_ca_system_score_gemma":0.001255984,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004350551,"about_ca_topic_score_gemma":0.003033716,"domain_scores_codex":[0.9987091,0.00007865372,0.0002229882,0.0003939533,0.0002267861,0.0003685117],"domain_scores_gemma":[0.9992284,0.00005933969,0.00005269716,0.0003503192,0.000131904,0.0001773284],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.05907571,0.0008091907,0.2274148,0.00009282739,0.001326969,0.0002735512,0.020029,0.0003722646,0.4485559,0.0001081642,0.1724804,0.06946124],"study_design_scores_gemma":[0.01121651,0.00194239,0.7097153,0.0005729189,0.0001532083,0.00001104047,0.0006617872,0.00008599021,0.06208215,0.00007814767,0.2129655,0.0005149989],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9868492,0.002183093,0.00005526241,0.005140058,0.0007382003,0.0008729468,0.0001407909,0.0001257758,0.003894668],"genre_scores_gemma":[0.9856066,0.0004256925,0.0002587816,0.005895676,0.0003742644,0.0005135041,0.00003670947,0.00004464915,0.006844133],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4823005,"threshold_uncertainty_score":0.657676,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01720782505662348,"score_gpt":0.3378055771221455,"score_spread":0.320597752065522,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}