{"id":"W2794724225","doi":"10.1093/infdis/jiy177","title":"A Respiratory Syncytial Virus Vaccine Based on the Small Hydrophobic Protein Ectodomain Presented With a Novel Lipid-Based Formulation Is Highly Immunogenic and Safe in Adults: A First-in-Humans Study","year":2018,"lang":"en","type":"article","venue":"The Journal of Infectious Diseases","topic":"Respiratory viral infections research","field":"Medicine","cited_by":60,"is_retracted":false,"has_abstract":true,"ca_institutions":"Immunovaccine (Canada); Nova Scotia Health Authority; Izaak Walton Killam Health Centre; Dalhousie University","funders":"Canadian Institutes of Health Research","keywords":"Ectodomain; Virus; Virology; Medicine; Respiratory system; Influenza vaccine; Respiratory tract; Immunology; Receptor; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002929318,0.001304351,0.001680496,0.000388006,0.0004222184,0.0007663563,0.000715883,0.001585841,0.001944689],"category_scores_gemma":[0.0008502229,0.0007229159,0.001119324,0.0002061312,0.00142966,0.001011699,0.0002873657,0.001920109,0.0004662262],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000578337,"about_ca_system_score_gemma":0.0007424208,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005234949,"about_ca_topic_score_gemma":0.0007674639,"domain_scores_codex":[0.9991708,0.0003971264,0.00004938246,0.0001542902,0.00009587994,0.0001324567],"domain_scores_gemma":[0.9991481,0.0001395355,0.0002396169,0.00009412551,0.0001088471,0.0002696344],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.5096844,0.1522137,0.002882089,0.001676877,0.001147846,0.0002173323,0.0003956357,0.0006607815,0.2938106,0.0001928883,0.0008181817,0.03629961],"study_design_scores_gemma":[0.04389566,0.9413581,0.002720213,0.00001591081,0.000308048,0.0000952468,0.00003327686,0.0001970921,0.01050486,0.00004351324,0.0008110711,0.0000168847],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969581,0.0006983445,0.0005780941,0.00008941071,0.00006800679,0.001218709,0.0001371839,0.00002442393,0.0002278589],"genre_scores_gemma":[0.9939588,0.001184019,0.001521996,0.0002551795,0.0002424857,0.0009473255,0.0002813254,0.00001623803,0.0015927],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002929318,"threshold_uncertainty_score":0.0154919,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02009944912437788,"score_gpt":0.2906149579952639,"score_spread":0.270515508870886,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}