{"id":"W2794769072","doi":"10.1128/aac.02045-17","title":"Dextromethorphan Attenuates NADPH Oxidase-Regulated Glycogen Synthase Kinase 3β and NF-κB Activation and Reduces Nitric Oxide Production in Group A Streptococcal Infection","year":2018,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"Streptococcal Infections and Treatments","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University","funders":"Ministry of Science and Technology, Taiwan","keywords":"NADPH oxidase; Nitric oxide synthase; Proinflammatory cytokine; GSK-3; Reactive oxygen species; Chemistry; Nitric oxide; Protein kinase B; Glycogen synthase; Pharmacology; Biology; Inflammation; Signal transduction; Biochemistry; Immunology; Phosphorylation; Endocrinology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001572825,0.0006247971,0.0003556907,0.0002641446,0.000134653,0.0001222423,0.000213546,0.0002523936,0.0008565235],"category_scores_gemma":[0.000136991,0.000145188,0.0003097305,0.0001195361,0.000254417,0.0001584708,0.0001928296,0.000529174,0.0001207635],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000146627,"about_ca_system_score_gemma":0.0002493262,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004012315,"about_ca_topic_score_gemma":0.0006160649,"domain_scores_codex":[0.9999095,0.00002193867,0.00001099019,0.00001276946,0.000018602,0.00002617357],"domain_scores_gemma":[0.9999084,0.000008924358,0.00003653129,0.00000826638,0.000007447867,0.00003051747],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000914178,0.0001584165,0.0001319561,0.00006252628,0.000008184949,0.00005424844,0.00001071613,0.00003812166,0.9971254,0.0000281627,0.00002871918,0.001439241],"study_design_scores_gemma":[0.0002143607,0.005692959,0.006969274,0.00002246312,0.00005058846,0.0003208368,0.00006269216,0.00105379,0.9842173,0.00005739201,0.001330747,0.000007647358],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968622,0.001667669,0.0007579543,0.00006683481,0.00004135467,0.00002560031,0.0000887194,0.00004741034,0.0004423036],"genre_scores_gemma":[0.9963068,0.001082473,0.001241543,0.00005000865,0.00001869591,0.00004768838,0.0001842554,0.000006615584,0.001062039],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008565235,"threshold_uncertainty_score":0.002865314,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01747193548191549,"score_gpt":0.2863451885418721,"score_spread":0.2688732530599566,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}