{"id":"W2794793589","doi":"10.1074/jbc.ra118.001902","title":"A three-way inter-molecular network accounts for the CaVα2δ1-induced functional modulation of the pore-forming CaV1.2 subunit","year":2018,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Montreal Heart Institute","funders":"Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research; Government of Canada; Heart and Stroke Foundation of Canada","keywords":"Cav1.2; Chemistry; Side chain; Alanine; Protein subunit; Carboxylate; Stereochemistry; Molecular dynamics; Hydrogen bond; Biophysics; Dimer; Extracellular; Crystallography; Amino acid; Biochemistry; Molecule; Biology; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001951548,0.0003224095,0.0002049877,0.0003070701,0.0005633606,0.0008617087,0.0007562379,0.0004845756,0.003533335],"category_scores_gemma":[0.0004663046,0.0002928176,0.0005970209,0.0001999887,0.0004380349,0.001487102,0.0006416252,0.0006809485,0.0010646],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005446842,"about_ca_system_score_gemma":0.0003540217,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004204369,"about_ca_topic_score_gemma":0.000434765,"domain_scores_codex":[0.9997928,0.0000258693,0.00001244921,0.00005931681,0.00006074391,0.00004891339],"domain_scores_gemma":[0.9996953,0.00003928049,0.00006485664,0.00005043262,0.00008337389,0.00006674028],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003514608,0.0001023464,0.003582494,0.0001840321,0.00009793859,0.0005521525,0.0001552641,0.009557729,0.937318,0.03170942,0.0009928436,0.01539636],"study_design_scores_gemma":[0.000182101,0.0008253856,0.05696576,0.00008500445,0.0004738202,0.001832814,0.0005253512,0.248993,0.5938865,0.06690677,0.0291831,0.0001404505],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.809832,0.002186656,0.1694238,0.001667349,0.0004470758,0.0001172687,0.0005157798,0.001081337,0.01472879],"genre_scores_gemma":[0.9913734,0.0004362741,0.00497413,0.00005480639,0.00003097731,0.00004121064,0.0001883928,0.00003170608,0.00286923],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003533335,"threshold_uncertainty_score":0.0118202,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03692159020367432,"score_gpt":0.2596568570387628,"score_spread":0.2227352668350885,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}