{"id":"W2794856460","doi":"10.1172/jci.insight.120159","title":"HDAC11 suppresses the thermogenic program of adipose tissue via BRD2","year":2018,"lang":"en","type":"article","venue":"JCI Insight","topic":"Adipose Tissue and Metabolism","field":"Medicine","cited_by":107,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Heart, Lung, and Blood Institute; National Institute on Aging; Cancer Center, University of Colorado; Canadian Institutes of Health Research; Nutrition Obesity Research Center, University of North Carolina; National Institutes of Health; American Heart Association","keywords":"Histone deacetylase; Biology; HDAC4; Adipose tissue; HDAC11; White adipose tissue; Cell biology; Histone; Acetylation; Histone deacetylase 5; Endocrinology; Internal medicine; Biochemistry; Medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001974608,0.0004193262,0.0003265463,0.0002735474,0.0001573948,0.0004292021,0.0003108099,0.0002373597,0.002242328],"category_scores_gemma":[0.00008595736,0.0002148683,0.0003238435,0.0001699388,0.0003089537,0.0001610515,0.0001941991,0.0007474319,0.0007132823],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002868787,"about_ca_system_score_gemma":0.0002396946,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006281601,"about_ca_topic_score_gemma":0.001959672,"domain_scores_codex":[0.9998553,0.00002591917,0.00001488149,0.00003189277,0.00003224702,0.00003967413],"domain_scores_gemma":[0.9999382,0.0000069181,0.00001885703,0.000008457726,0.000005588094,0.0000218938],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004023555,0.00008020234,0.0004125607,0.00006723234,0.00001654488,0.00006462231,0.00001098418,0.00008052169,0.9944877,0.0002431414,0.0003071964,0.003826884],"study_design_scores_gemma":[0.0001685555,0.0006693921,0.009297681,0.00001141842,0.00005325615,0.0003792697,0.00004984047,0.001188529,0.9742391,0.0001068394,0.01382736,0.000008783449],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9714026,0.008943412,0.006771268,0.001034715,0.0003501613,0.00006358534,0.001737218,0.0006065449,0.009090326],"genre_scores_gemma":[0.9869291,0.003158584,0.001645253,0.0002629939,0.00004252508,0.00003964219,0.001264697,0.00005789629,0.006599384],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002242328,"threshold_uncertainty_score":0,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02143071376594185,"score_gpt":0.3061482128239587,"score_spread":0.2847174990580168,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}