{"id":"W2794873645","doi":"10.1016/j.celrep.2018.02.104","title":"A Screen for Candidate Targets of Lysine Polyphosphorylation Uncovers a Conserved Network Implicated in Ribosome Biogenesis","year":2018,"lang":"en","type":"article","venue":"Cell Reports","topic":"RNA and protein synthesis mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":89,"is_retracted":false,"has_abstract":true,"ca_institutions":"Carleton University; University of Ottawa","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Lysine; Ribosome biogenesis; Biogenesis; Translation (biology); Biology; Ribosome; Computational biology; Conserved sequence; Cell biology; Genetics; Gene; Amino acid; RNA; Peptide sequence; Messenger RNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000362235,0.0001265068,0.0001947901,0.00004041739,0.00005069739,0.000007831028,0.00007640781,0.0001484356,0.00002810907],"category_scores_gemma":[0.0000748866,0.0001226898,0.00008991846,0.0001446486,0.00005844453,0.000003161575,0.0000433336,0.00002025435,0.0000016828],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001351976,"about_ca_system_score_gemma":0.0001017343,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005036753,"about_ca_topic_score_gemma":0.0002191985,"domain_scores_codex":[0.9989337,0.00003625776,0.0003771494,0.0003307282,0.00008266587,0.0002394838],"domain_scores_gemma":[0.9991163,0.000015275,0.0003041522,0.0003788331,0.0001273608,0.00005806992],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002326854,0.00003287012,0.01546525,0.00001839996,0.00002779016,0.000008841961,0.00001322322,0.00004191887,0.9823763,0.00001217853,0.001086678,0.000683916],"study_design_scores_gemma":[0.0003179664,0.0002569373,0.003196981,0.00001853264,0.00002211282,0.00001260929,0.000008231912,0.00003876637,0.9851064,0.000510868,0.01036952,0.0001410522],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9928446,0.0008954766,0.00505277,0.00005443185,0.0001553597,0.0005086326,0.00003133831,0.00000912697,0.0004482052],"genre_scores_gemma":[0.9966301,0.00005848273,0.002420179,0.00008325824,0.0001467688,0.00005398522,0.0002484774,0.0000222363,0.000336471],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01226827,"threshold_uncertainty_score":0.5003146,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00951375637358405,"score_gpt":0.2340401729980197,"score_spread":0.2245264166244357,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}