{"id":"W2794918098","doi":"10.3389/fmicb.2018.00629","title":"Stem Cell Transcription Factor FoxO Controls Microbiome Resilience in Hydra","year":2018,"lang":"en","type":"article","venue":"Frontiers in Microbiology","topic":"Marine Invertebrate Physiology and Ecology","field":"Earth and Planetary Sciences","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Exzellenzclusters Entzündungsforschung; Deutsche Forschungsgemeinschaft; Canadian Institute for Advanced Research","keywords":"Biology; Lernaean Hydra; Transcription factor; Microbiome; Epigenetics; Longevity; Holobiont; Innate immune system; Cell biology; Forkhead Transcription Factors; Regulator; Genetics; Model organism; Immune system; Gene; Bacteria","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008391702,0.0001329476,0.0001863874,0.0002020869,0.0002027916,0.0002947769,0.0001609288,0.0002209984,0.001252932],"category_scores_gemma":[0.0001543376,0.0001418312,0.0001959191,0.00009478022,0.0005318842,0.00024397,0.0007026611,0.0003675698,0.0002666339],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002551095,"about_ca_system_score_gemma":0.0002371224,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001034819,"about_ca_topic_score_gemma":0.001670232,"domain_scores_codex":[0.9999254,0.000005391596,0.000004379685,0.00002501843,0.00001496224,0.00002482695],"domain_scores_gemma":[0.9998647,0.00000975772,0.00004036248,0.000009663308,0.00001328101,0.00006220514],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001749199,0.000007346006,0.002766968,0.00002988392,0.000005212607,0.00005050962,0.00005958666,0.00007206955,0.9950571,0.0002185909,0.00007248091,0.001485198],"study_design_scores_gemma":[0.0001122786,0.0005709665,0.3704647,0.00004951917,0.0001184564,0.0005011333,0.001109492,0.005933829,0.6082221,0.001675182,0.01117713,0.00006512841],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970894,0.0005331855,0.0011366,0.0001024935,0.00002616862,0.000005826337,0.0002189833,0.00006917142,0.0008181689],"genre_scores_gemma":[0.9976009,0.0002245916,0.0004081224,0.00005391129,0.000005961824,0.000007928071,0.0001626183,0.00001715332,0.001518895],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001252932,"threshold_uncertainty_score":0.004191458,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007061205106345069,"score_gpt":0.1828746992995033,"score_spread":0.1758134941931583,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}