{"id":"W2794930605","doi":"10.1186/s12943-018-0804-2","title":"Kinase-targeted cancer therapies: progress, challenges and future directions","year":2018,"lang":"en","type":"review","venue":"Molecular Cancer","topic":"PI3K/AKT/mTOR signaling in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1300,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University; Acadia University; University of Alberta","funders":"","keywords":"Kinase; Biology; Kinome; Pharmacogenomics; Targeted therapy; Cancer; Drug development; Cancer research; Drug discovery; Tyrosine kinase; Pharmacology; Bioinformatics; Drug; Signal transduction; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02876374651707247,"score_gpt":0.3300517476278098,"score_spread":0.3012880011107373,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}