{"id":"W2794941286","doi":"10.1161/jaha.117.007928","title":"Experimental Right Ventricular Hypertension Induces Regional β1‐Integrin–Mediated Transduction of Hypertrophic and Profibrotic Right and Left Ventricular Signaling","year":2018,"lang":"en","type":"article","venue":"Journal of the American Heart Association","topic":"Pulmonary Hypertension Research and Treatments","field":"Medicine","cited_by":40,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Michael's Hospital; SickKids Foundation; Hospital for Sick Children; Canadian Heart Research Centre; University of Toronto","funders":"Heart and Stroke Foundation of Canada","keywords":"Internal medicine; Myofibroblast; Mechanotransduction; Fibrosis; Medicine; Cardiology; Pulmonary hypertension; Myocardial fibrosis; Extracellular matrix; Pulmonary artery; Endocrinology; Biology; Cell biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002484792,0.0006038967,0.0003966606,0.0003065217,0.000159278,0.000235359,0.0002495019,0.0003533702,0.00267473],"category_scores_gemma":[0.0001514442,0.0003019336,0.0003934031,0.0001247746,0.0004126343,0.0002944733,0.0002316659,0.001116751,0.0005491627],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002373638,"about_ca_system_score_gemma":0.0001789779,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002564202,"about_ca_topic_score_gemma":0.0005297589,"domain_scores_codex":[0.9996541,0.00006125587,0.00003460904,0.00006606313,0.0000816613,0.0001024907],"domain_scores_gemma":[0.9997533,0.00002589424,0.00009215403,0.00003391454,0.00001332468,0.00008137405],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003570685,0.0001168262,0.0003131073,0.00002962588,0.000007176133,0.0001320727,0.00001442909,0.00001535639,0.9981245,0.00005736591,0.00003953941,0.0007928891],"study_design_scores_gemma":[0.0002694794,0.004317502,0.02471366,0.00002500182,0.00006761774,0.001279938,0.00009919279,0.001182862,0.9659193,0.00010413,0.002008883,0.00001247005],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9942356,0.001313876,0.002501632,0.0001580137,0.0001041797,0.00005361902,0.0001844681,0.000137008,0.001311705],"genre_scores_gemma":[0.9943299,0.0008560764,0.001899149,0.0001119745,0.00007158078,0.00009716964,0.0003957678,0.00002416005,0.002214243],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00267473,"threshold_uncertainty_score":0.008947849,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01771276973817966,"score_gpt":0.2712841823846361,"score_spread":0.2535714126464565,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}