{"id":"W2794949547","doi":"10.3389/fgene.2018.00117","title":"Efficient Gene Transfer and Gene Editing in Sterlet (Acipenser ruthenus)","year":2018,"lang":"en","type":"article","venue":"Frontiers in Genetics","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":40,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Beijing Academy of Agricultural and Forestry Sciences; National Natural Science Foundation of China; University of Ottawa","keywords":"Transcription activator-like effector nuclease; CRISPR; Biology; Genome editing; Cas9; Gene; Nuclease; Guide RNA; Mutant; Genetics; Molecular biology; Cell biology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001909891,0.0001819944,0.000177677,0.0001201664,0.00003888003,0.00002015494,0.0001446406,0.0001623411,0.00000716561],"category_scores_gemma":[0.00002101694,0.0001991185,0.00003807222,0.0001328308,0.0001182611,0.000001194003,0.00007553344,0.0001043862,0.000002471223],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001966345,"about_ca_system_score_gemma":0.00002447254,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000008350788,"about_ca_topic_score_gemma":0.00005989966,"domain_scores_codex":[0.9988281,0.00003583004,0.0002632824,0.0003899168,0.0001146254,0.0003682106],"domain_scores_gemma":[0.999586,0.000004620991,0.00001883198,0.0002722417,0.00003646567,0.00008186071],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000136194,0.0001166656,0.09483849,0.00005740244,0.00005578009,0.00002687896,0.00166771,0.0161421,0.8647678,0.00001000705,0.001785641,0.02039529],"study_design_scores_gemma":[0.002276246,0.0004462792,0.04599036,0.00005123954,0.00002955121,0.00003962206,0.0005564888,0.03535916,0.8987053,0.00007586719,0.0158198,0.0006500779],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8977759,0.003837013,0.09694859,0.00003896828,0.0009957245,0.0001776253,0.00001513522,0.000007726888,0.0002032382],"genre_scores_gemma":[0.9761752,0.0003837669,0.02265204,0.000107937,0.0005083883,0.00001486483,0.00002216315,0.00003371561,0.0001019227],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07839923,"threshold_uncertainty_score":0.8119817,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004960123797178067,"score_gpt":0.2443900259553705,"score_spread":0.2394299021581925,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}