{"id":"W2794971102","doi":"10.1021/acs.jmedchem.8b00258","title":"Identification and Structure–Activity Relationship of HDAC6 Zinc-Finger Ubiquitin Binding Domain Inhibitors","year":2018,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":63,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network; Structural Genomics Consortium; University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada; Wellcome Trust","keywords":"Chemistry; Ubiquitin; Proteasome; Zinc finger; Binding domain; Ligand (biochemistry); Binding site; Biochemistry; Cell biology; Biophysics; Computational biology; Receptor; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000854196,0.0001192594,0.0001992371,0.00007920142,0.00009662864,0.0000145296,0.0001600675,0.0001947581,0.00005756003],"category_scores_gemma":[0.000830333,0.0001072647,0.00007272347,0.000139285,0.0004012744,0.00001306595,0.00006425157,0.0002880883,0.000002073885],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005895954,"about_ca_system_score_gemma":0.0001843445,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004820938,"about_ca_topic_score_gemma":0.000003933499,"domain_scores_codex":[0.9986614,0.00007131115,0.0004642242,0.0001830047,0.0004529797,0.0001670875],"domain_scores_gemma":[0.9986817,0.00005408816,0.0005410131,0.0002022781,0.0003758849,0.0001450289],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001843819,0.00003290651,0.003788813,0.00009602442,0.00003164113,0.000008347066,0.0001343576,0.000001127023,0.9927891,0.000004926398,0.002159287,0.0007690478],"study_design_scores_gemma":[0.0005726148,0.000223816,0.003002165,0.0001255864,0.00002637697,0.0003079219,0.0002251472,0.00000794269,0.9937288,0.00009447078,0.001592837,0.00009234734],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983071,0.000325757,0.0003690214,0.0002816087,0.0001708907,0.00005361901,0.000009624008,0.000002488642,0.0004798826],"genre_scores_gemma":[0.9978544,0.00002799102,0.0003164283,0.00001224047,0.001325089,0.000001004658,0.000009444805,0.00001461238,0.0004388338],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001154199,"threshold_uncertainty_score":0.4374126,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01224667483713535,"score_gpt":0.2944352013482189,"score_spread":0.2821885265110836,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}