{"id":"W2794971102","doi":"10.1021/acs.jmedchem.8b00258","title":"Identification and Structure–Activity Relationship of HDAC6 Zinc-Finger Ubiquitin Binding Domain Inhibitors","year":2018,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":63,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network; Structural Genomics Consortium; University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada; Wellcome Trust","keywords":"Chemistry; Ubiquitin; Proteasome; Zinc finger; Binding domain; Ligand (biochemistry); Binding site; Biochemistry; Cell biology; Biophysics; Computational biology; Receptor; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002182747,0.0004446775,0.0005120302,0.0004864376,0.0001596602,0.0003787359,0.0003741914,0.0002368109,0.002398155],"category_scores_gemma":[0.0002136354,0.0001673734,0.0003946317,0.000460364,0.0001180481,0.0002563765,0.0001912027,0.0004814629,0.0006544112],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004460168,"about_ca_system_score_gemma":0.0002705256,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009042344,"about_ca_topic_score_gemma":0.001455965,"domain_scores_codex":[0.9998742,0.00001798501,0.000009509048,0.00002109477,0.00004502786,0.00003207441],"domain_scores_gemma":[0.9999195,0.0000134676,0.00001551629,0.000007743312,0.00002324847,0.00002051113],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001118109,0.0008128607,0.002724651,0.0002477549,0.0001185016,0.0001854438,0.0000317001,0.005950275,0.9454613,0.0006639084,0.00080988,0.04187577],"study_design_scores_gemma":[0.0002420857,0.004866164,0.008117525,0.00001658758,0.0001928011,0.0008233099,0.00003012939,0.007367543,0.9653531,0.0002207587,0.01273995,0.00002995079],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9656261,0.01689949,0.005928871,0.0002233683,0.00004006691,0.0002203562,0.002337127,0.0001764066,0.008548195],"genre_scores_gemma":[0.980472,0.007294414,0.005199558,0.0001066284,0.0000206702,0.00005413668,0.00350495,0.0000203743,0.003327231],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002398155,"threshold_uncertainty_score":0.008022666,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01224667483713535,"score_gpt":0.2944352013482189,"score_spread":0.2821885265110836,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}