{"id":"W2795013773","doi":"10.1016/j.celrep.2018.03.017","title":"Serine Availability Influences Mitochondrial Dynamics and Function through Lipid Metabolism","year":2018,"lang":"en","type":"article","venue":"Cell Reports","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":257,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Cancer Institute; Canadian Institutes of Health Research; National Institutes of Health","keywords":"Serine; Ceramide; Biology; Cell biology; Biochemistry; Mitochondrion; Lipid metabolism; Sphingolipid; Glutamine; Amino acid; Apoptosis; Phosphorylation","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001564462,0.0001732168,0.0001983098,0.00002164413,0.0001264406,0.00003636249,0.00006720004,0.0001694448,0.00007419293],"category_scores_gemma":[0.00009416357,0.0001593725,0.00007864888,0.00008353037,0.0002408232,0.00001415974,0.0001111459,0.00008014026,0.00000778388],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001107578,"about_ca_system_score_gemma":0.0001043923,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001187498,"about_ca_topic_score_gemma":0.000252167,"domain_scores_codex":[0.9987356,0.00003646782,0.0003164825,0.0005403988,0.000141279,0.0002297535],"domain_scores_gemma":[0.9990448,0.000005218866,0.0001818339,0.000514506,0.0001630685,0.00009051721],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002513386,0.00009450115,0.003681681,0.00004743884,0.00005618947,0.000005013566,0.000134374,0.000007691271,0.9717463,0.00009955521,0.01337767,0.01049825],"study_design_scores_gemma":[0.0003285171,0.0001384435,0.01006717,0.000004306342,0.00006080178,0.00008753355,0.00004049377,0.00001919549,0.1619418,0.0003340405,0.8267761,0.0002014925],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9811017,0.003533464,0.001275948,0.000056228,0.007443356,0.0002159805,0.00001154274,0.00002542964,0.006336386],"genre_scores_gemma":[0.9825222,0.001285441,0.001467565,0.0003330807,0.009018033,0.00002613562,0.0001253263,0.00002785764,0.005194339],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8133985,"threshold_uncertainty_score":0.6499023,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007456237411464011,"score_gpt":0.2337402650298185,"score_spread":0.2262840276183545,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}