{"id":"W2795021885","doi":"10.1093/cid/ciy259","title":"Results From a Randomized, Placebo-Controlled Clinical Trial of a RBX2660—A Microbiota-Based Drug for the Prevention of Recurrent Clostridium difficile Infection","year":2018,"lang":"en","type":"article","venue":"Clinical Infectious Diseases","topic":"Clostridium difficile and Clostridium perfringens research","field":"Medicine","cited_by":140,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; Hamilton Regional Laboratory Medicine Program; Island Health; University of British Columbia","funders":"","keywords":"Medicine; Placebo; Clinical endpoint; Clostridium difficile; Adverse effect; Internal medicine; Randomized controlled trial; Clinical trial; Dosing; Efficacy; Antibiotics; Drug; Pharmacology; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.008129456,0.002237816,0.004214737,0.0004634848,0.0008044932,0.001278045,0.0009190619,0.003156512,0.01125155],"category_scores_gemma":[0.006087323,0.0008660186,0.00259109,0.0004354448,0.001476994,0.001364389,0.000515892,0.002904023,0.001367998],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006195793,"about_ca_system_score_gemma":0.002053809,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005460255,"about_ca_topic_score_gemma":0.0009598882,"domain_scores_codex":[0.9961836,0.0022756,0.0003930404,0.0005348552,0.0002968766,0.0003160271],"domain_scores_gemma":[0.9956291,0.00160515,0.001058061,0.0003642724,0.0005030344,0.0008403644],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9860244,0.004748383,0.000223542,0.000519603,0.0008015533,0.00002073781,0.00002204234,0.0001201691,0.001897966,0.00005885299,0.0005319803,0.005030714],"study_design_scores_gemma":[0.9457171,0.05155466,0.00103431,0.00004463379,0.0008069067,0.00001948404,0.000008023757,0.00009710474,0.0002655847,0.000077475,0.0003643948,0.00001028362],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9509761,0.01160133,0.002068332,0.002076014,0.001436017,0.02008456,0.005086212,0.0002209793,0.006450345],"genre_scores_gemma":[0.9677156,0.004503425,0.004024409,0.002379241,0.0009475141,0.01407108,0.003302793,0.00004942474,0.003006562],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01125155,"threshold_uncertainty_score":0.04299325,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06924328441621129,"score_gpt":0.4152262448054468,"score_spread":0.3459829603892355,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}