{"id":"W2795021885","doi":"10.1093/cid/ciy259","title":"Results From a Randomized, Placebo-Controlled Clinical Trial of a RBX2660—A Microbiota-Based Drug for the Prevention of Recurrent Clostridium difficile Infection","year":2018,"lang":"en","type":"article","venue":"Clinical Infectious Diseases","topic":"Clostridium difficile and Clostridium perfringens research","field":"Medicine","cited_by":140,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; Hamilton Regional Laboratory Medicine Program; Island Health; University of British Columbia","funders":"","keywords":"Medicine; Placebo; Clinical endpoint; Clostridium difficile; Adverse effect; Internal medicine; Randomized controlled trial; Clinical trial; Dosing; Efficacy; Antibiotics; Drug; Pharmacology; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaresearch","metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.005640751,0.0004134627,0.00292135,0.00023566,0.0002273744,0.00004515787,0.0002693181,0.0004030447,0.0002108703],"category_scores_gemma":[0.03971306,0.0002713359,0.003861337,0.0004941888,0.001928294,0.00006582158,0.0001327601,0.0006275869,0.00003332162],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001131832,"about_ca_system_score_gemma":0.001259302,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003996984,"about_ca_topic_score_gemma":0.0001866217,"domain_scores_codex":[0.9916781,0.001924238,0.004402228,0.0008726532,0.0006398974,0.0004829134],"domain_scores_gemma":[0.9665754,0.02876693,0.00184961,0.001112694,0.001317361,0.0003779399],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9589314,0.01078448,0.001913951,0.0001498013,0.001558905,0.000002559094,0.00003820957,0.0000200205,0.0005587375,0.00003521935,0.009250131,0.01675658],"study_design_scores_gemma":[0.9619648,0.0115535,0.002631611,0.0004653159,0.004583121,0.00000143735,0.00003223592,0.005132508,0.01097208,0.0002906241,0.002100035,0.0002727464],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9824196,0.0007145731,0.0011256,0.0009595312,0.003034449,0.01036425,0.0008981705,0.0001184545,0.0003653521],"genre_scores_gemma":[0.9934,0.001108791,0.00006692528,0.0001389492,0.003785618,0.0007511846,0.000393574,0.00005201085,0.0003029707],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03407231,"threshold_uncertainty_score":0.9999739,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06924328441621129,"score_gpt":0.4152262448054468,"score_spread":0.3459829603892355,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}