{"id":"W2795036950","doi":"10.1186/s13072-018-0182-4","title":"Depletion of DNMT1 in differentiated human cells highlights key classes of sensitive genes and an interplay with polycomb repression","year":2018,"lang":"en","type":"article","venue":"Epigenetics & Chromatin","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"Terry Fox Research Institute","funders":"Biotechnology and Biological Sciences Research Council; Economic and Social Research Council; Medical Research Council","keywords":"Biology; Small hairpin RNA; DNA methylation; DNMT1; Derepression; DNA methyltransferase; Methylation; Gene; Promoter; Psychological repression; Cell biology; Cancer research; Molecular biology; Methyltransferase; Genetics; Gene expression; Gene knockdown","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001684341,0.0001825087,0.0002593448,0.0001099149,0.00005824302,0.00001381723,0.0001100031,0.0001674759,0.00001008144],"category_scores_gemma":[0.00002160237,0.000156005,0.00003474072,0.0001134802,0.0002342666,0.000006266876,0.00009323181,0.00005496126,7.443811e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000009392047,"about_ca_system_score_gemma":0.0000329735,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001287536,"about_ca_topic_score_gemma":0.0006761581,"domain_scores_codex":[0.9986908,0.0001760865,0.0004255028,0.0003674928,0.0001619854,0.0001781564],"domain_scores_gemma":[0.9990432,0.00002349397,0.0002964577,0.000373812,0.0001937479,0.00006930468],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009461536,0.0001349511,0.02448795,0.00004187462,0.00002890803,0.000001401572,0.0004172977,0.0000462013,0.9739116,0.00005167368,0.000008322587,0.0007751727],"study_design_scores_gemma":[0.0005436219,0.001477753,0.1259229,0.0001042013,0.00002079254,0.000001319795,0.00008553067,0.0003821945,0.8711216,0.00008642361,0.00009564954,0.0001580039],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964666,0.0006107142,0.002377303,0.00001412075,0.00006504494,0.0002099456,0.00002132393,0.000007467304,0.0002275326],"genre_scores_gemma":[0.9954356,0.0003906707,0.003859419,0.000008779093,0.00009524967,0.000005535406,0.0001266049,0.00002735828,0.00005079188],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.10279,"threshold_uncertainty_score":0.6361699,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008917752320391178,"score_gpt":0.2797158207321238,"score_spread":0.2707980684117326,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}