{"id":"W2795065690","doi":"10.1016/j.tetlet.2018.03.084","title":"Solid-phase synthesis of homodetic cyclic peptides from Fmoc-MeDbz-resin","year":2018,"lang":"en","type":"article","venue":"Tetrahedron Letters","topic":"Chemical Synthesis and Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Institute of Population and Public Health; Inyuvesi Yakwazulu-Natali; Generalitat de Catalunya; King Saud University; National Research Foundation","keywords":"Chemistry; Cyclic peptide; Thiophenol; Cleavage (geology); Selectivity; Solid-phase synthesis; Side chain; Combinatorial chemistry; Amide; Stereochemistry; Peptide; Organic chemistry; Biochemistry; Catalysis","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001189084,0.0002106693,0.0003277505,0.00006423821,0.00006805459,0.00002144,0.0003261909,0.0001375114,0.0002878023],"category_scores_gemma":[0.0002167346,0.0001913224,0.0002572535,0.0001269413,0.0003665223,0.000005008681,0.00008425644,0.00007345857,0.00005934175],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002053909,"about_ca_system_score_gemma":0.00001921798,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002112418,"about_ca_topic_score_gemma":0.00005230354,"domain_scores_codex":[0.9986469,0.00006293652,0.0003393091,0.0004519504,0.0001910235,0.0003079513],"domain_scores_gemma":[0.9990808,0.00008336617,0.0001381352,0.0005407304,0.00004621912,0.0001107267],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006731681,0.0001365663,0.0009622969,0.0000109402,0.0001579923,0.0000035109,0.00003055994,0.000005543316,0.9884179,0.00000402979,0.003187724,0.007015602],"study_design_scores_gemma":[0.0003617107,0.0001008967,0.001663029,0.00003699091,0.0001298428,0.000001959321,0.00003654381,0.0001105813,0.9933309,0.00004461994,0.003945905,0.0002370263],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969262,0.00020638,0.001263899,0.0009041095,0.00006249741,0.0000688074,0.00007724421,0.00001945234,0.0004713997],"genre_scores_gemma":[0.9974788,0.0000573731,0.0009269625,0.0008281556,0.0005246989,0.00001480781,0.0000623516,0.00003091954,0.00007593047],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006778575,"threshold_uncertainty_score":0.7801901,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008282510833070455,"score_gpt":0.3004912076437609,"score_spread":0.2922086968106904,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}