{"id":"W2795075167","doi":"10.1038/s41579-018-0002-7","title":"CRISPR-based genomic tools for the manipulation of genetically intractable microorganisms","year":2018,"lang":"en","type":"review","venue":"Nature Reviews Microbiology","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":111,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Guelph","funders":"","keywords":"CRISPR; Biology; Genome editing; Computational biology; Identification (biology); Gene; Genetics; Cas9; Ecology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008278101,0.001249144,0.001519925,0.00198652,0.0002991223,0.001461525,0.001558086,0.001416235,0.002820561],"category_scores_gemma":[0.0008275515,0.0004250228,0.0005334637,0.00205374,0.001079808,0.001494486,0.00130966,0.002990745,0.00236649],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008611082,"about_ca_system_score_gemma":0.001406374,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008738085,"about_ca_topic_score_gemma":0.001671089,"domain_scores_codex":[0.9995875,0.00004457064,0.000036822,0.00005511019,0.0002236834,0.00005242488],"domain_scores_gemma":[0.9995399,0.0002178728,0.00006873989,0.00002658619,0.00009200747,0.00005500948],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00006641448,0.00006377729,0.0001099295,0.01272677,0.00008354905,0.000267462,0.00006130233,0.0006002223,0.02509576,0.01660791,0.04163022,0.9026867],"study_design_scores_gemma":[0.000009357236,0.00003077262,0.0002456516,0.0009074086,0.00004620307,0.0006167528,0.00002216446,0.00007734438,0.004594534,0.003117913,0.9903098,0.000021983],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001843275,0.9947917,0.002111886,0.0004978269,0.0004741996,0.000008175003,0.00004733488,0.0000596255,0.001824841],"genre_scores_gemma":[0.001306241,0.9957578,0.001103321,0.0003156587,0.0001886522,0.000009031219,0.00009312922,0.000008900374,0.001217358],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002820561,"threshold_uncertainty_score":0.009435713,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03069972816619101,"score_gpt":0.366325403412361,"score_spread":0.3356256752461699,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}