{"id":"W2795084096","doi":"10.1371/journal.pone.0194185","title":"HIV induces production of IL-18 from intestinal epithelial cells that increases intestinal permeability and microbial translocation","year":2018,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Inflammasome and immune disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université du Québec à Montréal; McGill University; Université de Montréal","funders":"Fondation des Etoiles","keywords":"Adherens junction; Occludin; Tight junction; Cytokine; Myosin light-chain kinase; Cell biology; Biology; Intestinal permeability; Proinflammatory cytokine; Molecular biology; Inflammation; Immunology; Phosphorylation; Cadherin; Cell; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007144449,0.000193446,0.0001801271,0.0001786114,0.00009644218,0.0002251684,0.00006579509,0.0002088062,0.001487369],"category_scores_gemma":[0.0000883543,0.0001183414,0.0002247337,0.0001240716,0.0001079701,0.000112157,0.0001491091,0.0005923595,0.0002885456],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001084542,"about_ca_system_score_gemma":0.00008163049,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001525519,"about_ca_topic_score_gemma":0.0002316051,"domain_scores_codex":[0.9998947,0.00001794898,0.00000916199,0.0000134253,0.00003192209,0.00003270981],"domain_scores_gemma":[0.9999243,0.00001620379,0.00002110464,0.00001141528,0.000009706965,0.00001727739],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001468168,0.00006004853,0.0004624109,0.00006390121,0.000007191047,0.0002373086,0.00002841785,0.00001966937,0.9965143,0.00005581606,0.0001262398,0.002277927],"study_design_scores_gemma":[0.00006784089,0.0008565524,0.0203906,0.00002632302,0.00003296562,0.001531298,0.00009778129,0.0006582715,0.9668093,0.0001244526,0.009397085,0.000007488151],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9906736,0.004927019,0.001649195,0.0002139618,0.0001228272,0.0000385048,0.0004495372,0.00008411297,0.001841291],"genre_scores_gemma":[0.9924589,0.002521742,0.00210785,0.0001635444,0.00004607577,0.00005618692,0.0006606722,0.0000114066,0.001973699],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001487369,"threshold_uncertainty_score":0.004975736,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02396409923938799,"score_gpt":0.2179259273537725,"score_spread":0.1939618281143845,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}