{"id":"W2795084096","doi":"10.1371/journal.pone.0194185","title":"HIV induces production of IL-18 from intestinal epithelial cells that increases intestinal permeability and microbial translocation","year":2018,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Inflammasome and immune disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université du Québec à Montréal; McGill University; Université de Montréal","funders":"Fondation des Etoiles","keywords":"Adherens junction; Occludin; Tight junction; Cytokine; Myosin light-chain kinase; Cell biology; Biology; Intestinal permeability; Proinflammatory cytokine; Molecular biology; Inflammation; Immunology; Phosphorylation; Cadherin; Cell; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000133122,0.0001184593,0.0001454488,0.00003165834,0.00006506223,0.00001244863,0.00009803531,0.00008084942,0.0000508319],"category_scores_gemma":[0.0002249346,0.0001165408,0.00003439445,0.00005090954,0.0003265848,0.00001086539,0.00004540971,0.00007364861,0.000007901062],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000007344335,"about_ca_system_score_gemma":0.00005669722,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002134289,"about_ca_topic_score_gemma":0.00005654458,"domain_scores_codex":[0.9992273,0.00006564618,0.0001854644,0.0002939129,0.00009994919,0.0001276789],"domain_scores_gemma":[0.9994538,0.00001375578,0.00009298568,0.000210765,0.0001973279,0.00003134559],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003353206,0.000549665,0.01194218,0.00004394815,0.00006268739,1.762285e-7,0.0002370805,4.496041e-7,0.9852965,0.000002065984,0.00008909432,0.001440804],"study_design_scores_gemma":[0.0003637056,0.0004082719,0.01730263,0.00009420093,0.00006483385,0.000003110702,0.0001506847,0.00001935543,0.98131,0.00008514976,0.00007118386,0.0001268582],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9991929,0.0001569006,0.0001344761,0.0001107173,0.00006399401,0.0001918079,0.00004537352,0.00001067077,0.00009318699],"genre_scores_gemma":[0.9976991,0.0001058134,0.001538634,0.00003138603,0.000357779,0.00001101455,0.0001773629,0.00001174478,0.00006718309],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005360448,"threshold_uncertainty_score":0.4752396,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02396409923938799,"score_gpt":0.2179259273537725,"score_spread":0.1939618281143845,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}