{"id":"W2795103913","doi":"10.1093/infdis/jiy176","title":"HIV-1 Resistance Dynamics in Patients With Virologic Failure to Dolutegravir Maintenance Monotherapy","year":2018,"lang":"en","type":"article","venue":"The Journal of Infectious Diseases","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":79,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital","funders":"","keywords":"Dolutegravir; Integrase; Virology; Integrase inhibitor; Drug resistance; Medicine; Viral load; Human immunodeficiency virus (HIV); Biology; Genetics; Antiretroviral therapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001408206,0.0001507579,0.0002665418,0.0001562194,0.0000863573,0.00001440856,0.0001060357,0.00003088106,0.00004384019],"category_scores_gemma":[0.00006733481,0.0000733628,0.00006002055,0.0002999461,0.0001001388,0.00007826319,0.00001563873,0.0001330923,0.00003236729],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004068238,"about_ca_system_score_gemma":0.0001098977,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000007373833,"about_ca_topic_score_gemma":0.0006010619,"domain_scores_codex":[0.9991091,0.00006787892,0.0002611678,0.00009920407,0.0002597223,0.0002029646],"domain_scores_gemma":[0.9991854,0.00005626191,0.0001823456,0.0001805001,0.0002596846,0.0001358276],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00359961,0.0005478978,0.9894051,0.00001079004,0.00013966,0.00003629332,0.000389274,0.00001849853,0.000008161645,0.0001124568,0.005156431,0.0005758265],"study_design_scores_gemma":[0.005748166,0.001363478,0.9895307,0.0003054031,0.000167296,0.00003045916,0.0002072233,0.00002178035,0.00004797311,0.0003540526,0.002097973,0.0001255189],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9950766,0.0001225188,0.0006950292,0.003094521,0.00006349144,0.0003171232,0.00001487236,0.00001763547,0.0005982048],"genre_scores_gemma":[0.9975022,0.00005827424,0.0004372227,0.0006185856,0.00009193098,0.000006916543,0.000005488534,0.00001689445,0.001262496],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003058458,"threshold_uncertainty_score":0.2991648,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003089663807920755,"score_gpt":0.2128574755234662,"score_spread":0.2097678117155454,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}