{"id":"W2795103913","doi":"10.1093/infdis/jiy176","title":"HIV-1 Resistance Dynamics in Patients With Virologic Failure to Dolutegravir Maintenance Monotherapy","year":2018,"lang":"en","type":"article","venue":"The Journal of Infectious Diseases","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":79,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital","funders":"","keywords":"Dolutegravir; Integrase; Virology; Integrase inhibitor; Drug resistance; Medicine; Viral load; Human immunodeficiency virus (HIV); Biology; Genetics; Antiretroviral therapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003814408,0.0002871367,0.000425231,0.0005134433,0.0005940851,0.0008286124,0.0002218058,0.0005541288,0.001381376],"category_scores_gemma":[0.002130683,0.0001629199,0.0002061898,0.0004564505,0.0002723033,0.000427381,0.0002572722,0.0005676237,0.0002324436],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004540639,"about_ca_system_score_gemma":0.0002862866,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001056887,"about_ca_topic_score_gemma":0.000881292,"domain_scores_codex":[0.9997268,0.0000421544,0.00002862817,0.00007628299,0.00004917812,0.00007693189],"domain_scores_gemma":[0.9990638,0.0002811512,0.0003287988,0.00003334259,0.00007282101,0.000220127],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0008289564,0.0000756399,0.9884554,0.00001462481,0.00002826397,0.001418563,0.0002478829,0.000191577,0.001736982,0.0000331782,0.0002101946,0.006758664],"study_design_scores_gemma":[0.0000817413,0.00158839,0.9888672,0.0000202515,0.00004248021,0.006974549,0.0004436579,0.0008318496,0.000575148,0.00008873991,0.0004702102,0.00001571293],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9993021,0.0002137247,0.0000451053,0.00003184629,0.000001856691,0.000006816425,0.00006385476,0.000004980073,0.0003295752],"genre_scores_gemma":[0.9997584,0.00003849393,0.00004201621,0.00002902426,0.000006991151,0.000005715297,0.00007900589,0.000001528633,0.00003881046],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001381376,"threshold_uncertainty_score":0.004621148,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003089663807920755,"score_gpt":0.2128574755234662,"score_spread":0.2097678117155454,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}